(3,4-二甲氧基苯基)丙酮酸合成路线 （共 14 条）
参考文献
Snyder; Buck; Ide
Organic Syntheses, 1935 , vol. 15, p. 33
Organic Syntheses, 1943 , vol. Coll. Vol. II, p. 335
参考文献
Cain; Simonsen; Smith
Journal of the Chemical Society, 1913 , vol. 103, p. 1038
参考文献
Niederl; Ziering
Journal of the American Chemical Society, 1942 , vol. 64, p. 885
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Julian; Sturgis
Journal of the American Chemical Society, 1935 , vol. 57, p. 1126
反应条件
1: p-toluenesulfonic acid / benzene / Heating 2: 99 percent / aq. acid / 1 h / Ambient temperature View Scheme
参考文献
Stamos, Ioannis K.
Tetrahedron Letters, 1982 , vol. 23, # 4 p. 459 - 462
反应条件
sodium hydroxide; dihydrogen peroxide Erwaermen des Reaktionsprodukts mit Methanol unter Zusatz von Schwefelsaeure;
参考文献
Snyder; Buck; Ide
Org. Synth. Coll. Vol., 1943 , vol. II, p. 333,334
反应条件
1.1: n-BuLi / tetrahydrofuran 1.2: iodine / tetrahydrofuran 2.1: NH3; TiCl4 / tetrahydrofuran 3.1: sodium hypochlorite 3.2: 78 percent / sodium hydrogensulfite 4.1: KOH 4.2: HCl View Scheme
参考文献
Lee, Jae Yeol; Yoon, Kwon Joong; Lee, Yong Sup
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4331 - 4334
反应条件
potassium hydroxide in water
6.5 h; Heating;
参考文献
Pharmazie, 1988 , vol. 43, # 3 p. 166 - 167
反应条件
hydrogenchloride; sodium hydroxide
1.) steam bath, 2.) reflux, 4 h; Multistep reaction;
参考文献
Audia, James E.; Evrard, Deborah A.; Murdoch, Gwyn R.; Droste, James J.; Nissen, Jeffrey S.; Schenck, Kathy W.; Fludzinski, Pawel; Lucaites, Virginia L.; Nelson, David L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2773 - 2780
反应条件
1: Ac2O, AcONa / 4 h / 100 °C
2: 1.) 1.0 N aq. NaOH, 2.) aq. HCl / 1.) steam bath, 2.) reflux, 4 h
View Scheme
参考文献
Audia, James E.; Evrard, Deborah A.; Murdoch, Gwyn R.; Droste, James J.; Nissen, Jeffrey S.; Schenck, Kathy W.; Fludzinski, Pawel; Lucaites, Virginia L.; Nelson, David L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2773 - 2780
反应条件
potassium hydroxide; water
Heating;
参考文献
Yli-Kauhaluoma, Jari T.; Janda, Kim D.
Tetrahedron Letters, 1994 , vol. 35, # 26 p. 4509 - 4510
