4-溴-2,6-二甲基苯胺合成路线

Guillemont, Jerome; Pasquier, Elisabeth; Palandjian, Patrice; Vernier, Daniel; Gaurrand, Sandrine; Lewi, Paul J.; Heeres, Jan; De Jonge, Marc R.; Koymans, Lucien M. H.; Daeyaert, Frits F. D.; Vinkers, Maarten H.; Arnold, Eddy; Das, Kalyan; Pauwels, Rudi; Andries, Koen; De Bethune, Marie-Pierre; Bettens, Eva; Hertogs, Kurt; Wigerinck, Piet; Timmerman, Philip; Janssen, Paul A. J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2072 - 2079

50-00-0甲醛+

64-18-6甲酸+

24596-19-84-溴-2,6-二甲基苯胺

→

50638-54-54-溴-N,N,2,6-四甲基苯胺

参考文献

Takeda Pharmaceutical Company Limited
Patent: EP1927596 A1, 2008 ;
Location in patent: Page/Page column 20-21 ;

50-00-0甲醛+

24596-19-84-溴-2,6-二甲基苯胺

→

50638-54-54-溴-N,N,2,6-四甲基苯胺

参考文献

Inoguchi; Achiwa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 3 p. 818 - 820

24596-19-84-溴-2,6-二甲基苯胺+

244768-32-94-[(4-氯-2-嘧啶基)氨基]苯腈

→

374067-85-34-[[4-[(4-溴-2,6-二甲基苯基)氨基]-2-吡啶]氨基]-苯甲腈

参考文献

JANSSEN PHARMACEUTICA N.V.; GUILLEMONT, Jerome, Emile, Georges
Patent: WO2004/16581 A1, 2004 ;
Location in patent: Page 20-21 ;