4-氯-2,6-二甲基苯胺合成路线 （共 10 条）
反应条件
hydrogenchloride in tetrahydrofuran 7 h; Heating;
参考文献
Corbo, Filomena; Franchini, Carlo; Lentini, Giovanni; Muraglia, Marilena; Ghelardini, Carla; Matucci, Rosanna; Galeotti, Nicoletta; Vivoli, Elisa; Tortorella, Vincenzo
Journal of Medicinal Chemistry, 2007 , vol. 50, # 8 p. 1907 - 1915
反应条件
1: 84 percent / CuCl / dimethylsulfoxide / 6 h / 188 °C 2: 98 percent / aq. HCl / tetrahydrofuran / 7 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 8 p. 1907 - 1915
反应条件
1: 47 percent / tetrahydrofuran / 14 h / 20 °C 2: 84 percent / CuCl / dimethylsulfoxide / 6 h / 188 °C 3: 98 percent / aq. HCl / tetrahydrofuran / 7 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 8 p. 1907 - 1915
反应条件
chlorine; acetic acid
参考文献
Journal of the Chemical Society, , p. 1106
反应条件
perchloric acid; sodium perchlorate; sodium chloride in water; acetonitrile T=25°C; Rate constant;
参考文献
Canadian Journal of Chemistry, , vol. 74, # 7 p. 1321 - 1328
反应条件
T=10 - 15°C; beim Chlorieren;
参考文献
Journal of the Chemical Society, , p. 1106
反应条件
und anschliessenden Hydrolysieren;
参考文献
Journal of the Chemical Society, , p. 2982,2986
反应条件
carbon dioxide; aluminium; 1-n-butyl-3-methylimidazolium bistrifluoromethylsulfonylamide T=45°C; Ullmann reaction; P=116262 Torr; 10 h;
参考文献
Cheng, Jinsheng; Zhang, Gencheng; Du, Jin; Tang, Longhua; Xu, Jingying; Li, Jinghong
Journal of Materials Chemistry, 2011 , vol. 21, # 10 p. 3485 - 3494
反应条件
palladium (II) trifluoroacetate; 2-(di-tert-butylphosphino)-1-(2,6-diisopropylphenyl)-1H-imidazole; sodium carbonate in N,N-dimethyl acetamide T=140°C; 16 h; Inert atmosphere;
参考文献
Schareina, Thomas; Jackstell, Ralf; Schulz, Thomas; Zapf, Alexander; Cotte, Alain; Gotta, Matthias; Beller, Matthias
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 4 p. 643 - 648
反应条件
1: With hydrogen bromide in water T=80°C; Sandmeyer Reaction; 2: With sodium nitrite in water T=-10 - -5°C; Sandmeyer Reaction; 0.666667 h; 3: With iron sulphate heptahydrate; hydrogen bromide in water T=-10 - 80°C; Sandmeyer Reaction; 1.41667 h; Product distribution / selectivity;
参考文献
Bayer CropScience AG
Patent: US2010/234652 A1, 2010 ;
Location in patent: Page/Page column 4 ;
