4-羟基-3-甲氧基-2-硝基苯甲醛合成路线 （共 31 条）
反应条件
1: diluted KOH-solution
2: acetic acid anhydride / 100 °C
3: ferrosulfate; ammonia
4: pentyl nitrite / Diazotization.Behandeln mit Kupferpulver
View Scheme
参考文献
Pschorr
Chemische Berichte, 1906 , vol. 39, p. 3115
反应条件
1: 97 percent / NaOH
2: 92 percent / KMnO4
View Scheme
参考文献
Pisovschi
Chemische Berichte, 1910 , vol. 43, p. 2140
反应条件
bromine; iodine; acetic acid
参考文献
Ojo; Chowdhury
Synthetic Communications, 1995 , vol. 25, # 4 p. 569 - 572
反应条件
1: NO2/HNO3 / acetic acid
2: Al(OiPr)3 / propan-2-ol
3: (i) H2, aq. HCl, Pd-C, (ii) aq. FeCl3
4: K2CO3 / acetone
5: aq. Na2S2O3 / diethyl ether
7: aq. FeCl3 / diethyl ether
View Scheme
参考文献
Koshi,K.; Shimizu,M.
Chemical and Pharmaceutical Bulletin, 1968 , vol. 16, p. 2343 - 2350
反应条件
1: 90 percent / acetic acid / 24 h / 60 °C
2: 50 percent / Cu / quinoline / 0.08 h / Heating
View Scheme
参考文献
Yoshida; Nagai; Oda; Sakakibara
Synthesis, 1986 , vol. No. 12, p. 1026 - 1027
反应条件
boron tribromide in dichloromethane
T=-78°C;
参考文献
Williams, Robert M.; Cushing, Timothy D.
Tetrahedron Letters, 1990 , vol. 31, # 44 p. 6325 - 6328
参考文献
Insole, Joan M.
Journal of Chemical Research, Miniprint, 1990 , # 12 p. 2831 - 2867
反应条件
potassium hydroxide
T=100°C; unter Druck;
参考文献
Magnus, Philip; Gazzard, Lewis; Hobson, Lindsay; Payne, Andrew H.; Rainey, Trevor J.; Westlund, Neil; Lynch, Vince
Tetrahedron, 2002 , vol. 58, # 17 p. 3423 - 3444
反应条件
sodium hydroxide; sodium carbonate; dimethyl sulfate in hexane; water; ethyl acetate; toluene
参考文献
Pfizer Inc.
Patent: US4287341 A1, 1981 ;
反应条件
1: 97 percent / NaOH
2: 92 percent / KMnO4
3: 82 percent / FeSO4, NH3
View Scheme
参考文献
Pschorr; Sumuleanu
Chemische Berichte, 1899 , vol. 32, p. 3407
