N-苄氧羰基-D-苯丙氨酸合成路线 （共 60 条）
反应条件
2: 25percent HBr, acetic acid View Scheme
参考文献
Chemical and pharmaceutical bulletin, , vol. 33, # 12 p. 5301 - 5309
反应条件
polymer-supported Thermococcus litoralis L-aminoacylase T=20°C; pH=8; aq. bufferEnzymatic reaction;
参考文献
Ngamsom; Hickey; Greenway; Littlechild; Watts; Wiles
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 63, # 1-2 p. 81 - 86
参考文献
Okada; Tsuda; Teno; Nagamatsu; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1985 , vol. 33, # 12 p. 5301 - 5309
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C; 22 h;
参考文献
Pettit, George R.; Hogan, Fiona; Herald, Delbert L.
Journal of Organic Chemistry, 2004 , vol. 69, # 12 p. 4019 - 4022
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / 0 °C
2: CH2Cl2 / 3 h / Ambient temperature
3: LAH / tetrahydrofuran / 1 h / 0 - 25 °C
4: VCl3(THF)3, Zn-Cu / CH2Cl2 / 3 h / Ambient temperature
5: N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature
6: cyclohexene / 20percent Pd(OH)2/C / ethanol / 18 h / Heating
7: CH2Cl2 / 18 h / Heating
8: NaH / dimethylformamide / 18 h / Ambient temperature
9: 4 N HCl / methanol; dioxane / 18 h / Ambient temperature
View Scheme
参考文献
Nugiel; Jacobs; Worley; Patel; Kaltenbach III; Meyer; Jadhav; De Lucca; Smyser; Klabe; Bacheler; Rayner; Seitz
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2156 - 2169
反应条件
1: Et3N; EDAC; HOBt / dimethylformamide / 20 °C
2: TFA; (CF3CO2)2IPh / CH2Cl2 / 0 °C
3: H2 / Pd/C / ethyl acetate / 12 h / 750.06 Torr
4: 100 percent / aq. HCl; H2 / Pd/C / ethanol / 33 h / 25 °C / 2250.18 Torr / pH 3
5: Et3N / CH2Cl2 / 20 °C
View Scheme
参考文献
Birch, Alan M.; Kenny, Peter W.; Oikonomakos, Nikos G.; Otterbein, Ludovic; Schofield, Paul; Whittamore, Paul R.O.; Whalley, Dave P.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 394 - 399
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / 0 °C
2: CH2Cl2 / 3 h / Ambient temperature
3: LAH / tetrahydrofuran / 1 h / 0 - 25 °C
4: VCl3(THF)3, Zn-Cu / CH2Cl2 / 3 h / Ambient temperature
5: N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature
6: cyclohexene / 20percent Pd(OH)2/C / ethanol / 18 h / Heating
7: CH2Cl2 / 18 h / Heating
8: NaH / dimethylformamide / 18 h / Ambient temperature
9: 4 N HCl / methanol; dioxane / 18 h / Ambient temperature
View Scheme
参考文献
Nugiel; Jacobs; Worley; Patel; Kaltenbach III; Meyer; Jadhav; De Lucca; Smyser; Klabe; Bacheler; Rayner; Seitz
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2156 - 2169
反应条件
1: dicyclohexylcarbodiimide (DCC) / CHCl3 / 6 h / Ambient temperature
2: 77 percent / benzyltrimethylammonium chloride / CHCl3 / 3 h / Ambient temperature
View Scheme
参考文献
Chen; Wang
Journal of the Chemical Society - Series Chemical Communications, 1990 , # 15 p. 1045 - 1047
反应条件
solid phase synthesis; Yield given. Multistep reaction;
参考文献
Juby, Carl D.; Richardson, Christopher D.; Brousseau, Roland
Tetrahedron Letters, 1991 , vol. 32, # 7 p. 879 - 882
反应条件
sodium hydroxide; diethyl ether; phosphorus pentachloride
Hydrieren des Reaktionsprodukts an Palladium in wss. Essigsaeure enthaltendem Methanol;
参考文献
Synge
Biochemical Journal, 1948 , vol. 42, p. 99,101
