N-苄氧羰基-D-苯丙氨酸合成路线 （共 60 条）
反应条件
dicyclohexyl-carbodiimide in ethyl acetate
参考文献
Yano, Yoshihiro; Shimada, Kenji; Okai, Jiro; Goto, Koichi; Matsumoto, Yoko; Ueoka, Ryuichi
Journal of Organic Chemistry, 2003 , vol. 68, # 4 p. 1314 - 1318
反应条件
1: (i) ClCO2Et, Et3N, (ii) NH3 2: H2 / Pd-C / aq. acetic acid View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 5, p. 555 - 566
参考文献
Guillaumie; Kappel; Kelly; Barany; Jensen
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6131 - 6135
反应条件
Reaktion ueber mehrere Stufen;
参考文献
Vejdelek
Collection of Czechoslovak Chemical Communications, 1950 , vol. 15, p. 929,931
反应条件
1: 84 percent / BH3 / tetrahydrofuran / 0 - 20 °C 2: Pyr*SO3; Et3N / dimethylsulfoxide; CH2Cl2 / 5 - 20 °C 3: 65 percent / TFA; Py / CH2Cl2 / 0 - 20 °C 4: 29 percent / H2 / Pd/C View Scheme
参考文献
Semple, J. Edward; Owens, Timothy D.; Nguyen, Khanh; Levy, Odile E.
Organic Letters, 2000 , vol. 2, # 18 p. 2769 - 2772
反应条件
borane in tetrahydrofuran T=0 - 20°C; Reduction;
参考文献
Semple, J. Edward; Owens, Timothy D.; Nguyen, Khanh; Levy, Odile E.
Organic Letters, 2000 , vol. 2, # 18 p. 2769 - 2772
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran T=24°C; 6 h;
参考文献
Sosnovsky; Prakash; Rao
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 1 - 10
反应条件
2: 25percent HBr, acetic acid View Scheme
参考文献
Okada; Tsuda; Teno; Nagamatsu; Okamoto; Nishi
Chemical and pharmaceutical bulletin, 1985 , vol. 33, # 12 p. 5301 - 5309
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / 0 °C 2: CH2Cl2 / 3 h / Ambient temperature 3: LAH / tetrahydrofuran / 1 h / 0 - 25 °C 4: VCl3(THF)3, Zn-Cu / CH2Cl2 / 3 h / Ambient temperature 5: N,N-diisopropylethylamine / dimethylformamide / 18 h / Ambient temperature 6: cyclohexene / 20percent Pd(OH)2/C / ethanol / 18 h / Heating 7: CH2Cl2 / 18 h / Heating 8: NaH / dimethylformamide / 18 h / Ambient temperature 9: 4 N HCl / methanol; dioxane / 18 h / Ambient temperature View Scheme
参考文献
Nugiel; Jacobs; Worley; Patel; Kaltenbach III; Meyer; Jadhav; De Lucca; Smyser; Klabe; Bacheler; Rayner; Seitz
Journal of Medicinal Chemistry, 1996 , vol. 39, # 11 p. 2156 - 2169
参考文献
Kessler, Horst; Becker, Guenther; Kogler, Herbert; Wolff, Michael
Tetrahedron Letters, 1984 , vol. 25, # 36 p. 3971 - 3974
