4-[4-(2-甲基-2-丙基)苯基]丁酸合成路线 （共 12 条）
反应条件
potassium hydroxide; hydrazine in ethylene glycol 8 h; Reflux;
参考文献
TOTAL PETROCHEMICALS RESEARCH FELUY; GOSUDARSTVENNOE UCHEBNO-NAUCHNOE UCHREZHDENIE KHIMICHESKY FAKULTET MOSKOVSKOGO GOSUDARSTVENNOGO UNIVERSITETA IM. M.V.LOMONOSOVA; VOSKOBOYNIKOV, Alexander, Z.; IZMER, Vyatcheslav, V.; KONONOVICH, Dmitry, S.; RAZAVI, Abbas
Patent: WO2010/76188 A1, 2010 ;
Location in patent: Page/Page column 13-15 ;
反应条件
hydrogenchloride; acetic acid; aluminium trichloride in dichloromethane; water; toluene
参考文献
Pennwalt Corporation
Patent: US4855462 A1, 1989 ;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5716944 A1, 1998 ;
反应条件
1: 57 percent / AlCl3 / various solvent(s) 2: NH2NH2*H2O, KOH / ethane-1,2-diol / 3 h / Heating 3: KOH / ethane-1,2-diol / 12 h / Heating View Scheme
参考文献
Jackson, Richard A.; Rhodes, Christopher J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 1 p. 53 - 57
反应条件
anschliessend Hydrolyse und Decarboxylierung;
参考文献
Cagniant; Buu-Hoi
Bulletin de la Societe Chimique de France, 1942 , vol. <5> 9, p. 111,117
反应条件
dimethylsulfide; oxygen; 2-methylpropane-2-thiol 1) benzene, irradiation, 2 h, 2) MeOH, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 33, # 1 p. 83 - 84
反应条件
acridine acid; dimethylsulfide multistep reaction; other carboxylic acids; other solvents, also with phenanthridine; Product distributionMechanism;
参考文献
Tetrahedron Letters, , vol. 33, # 1 p. 83 - 84
反应条件
1: PCl5 / benzene / 0.08 h / Heating
2: SnCl4 / benzene / 6 h / 0 °C
3: 31 percent / diethyl ether / 0.5 h / Heating
4: 80 percent / HCO2H
5: 61 percent / 10percent Pd/C / 0.75 h / 260 - 290 °C
View Scheme
参考文献
Jackson, Richard A.; Rhodes, Christopher J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 1 p. 53 - 57
反应条件
dimethylsulfide; oxygen; 2-methylpropane-2-thiol
1) benzene, irradiation, 2 h, 2) MeOH, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Okada, Keiji; Okubo, Katsura; Oda, Masaji
Tetrahedron Letters, 1992 , vol. 33, # 1 p. 83 - 84
反应条件
acridine acid; dimethylsulfide
multistep reaction; other carboxylic acids; other solvents, also with phenanthridine; Product distributionMechanism;
参考文献
Okada, Keiji; Okubo, Katsura; Oda, Masaji
Tetrahedron Letters, 1992 , vol. 33, # 1 p. 83 - 84
