2-(叔丁氧基羰基氨基)-4-甲基噻唑-5-羧酸乙酯合成路线 （共 3 条）
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=0 - 20°C;
参考文献
NOVARTIS AG; XENON PHARMACEUTICALS INC.
Patent: WO2009/103739 A1, 2009 ;
Location in patent: Page/Page column 78-79 ;
WO 2009/103739 A1
反应条件
1: ethanol / Heating 2: Et3N; DMAP / tetrahydrofuran / 20 °C View Scheme
参考文献
Kim, Hwa-Ok; Kahn, Michael
Synlett, 1999 , # 8 p. 1239 - 1240
反应条件
potassium hydroxide in tetrahydrofuran; ethanol T=55°C;
参考文献
Das, Jagabandhu; Padmanabha, Ramesh; Chen, Ping; Norris, Derek J.; Doweyko, Arthur M.P.; Barrish, Joel C.; Wityak, John; Lombardo, Louis J.; Lee, Francis Y.F.
Patent: US2004/54186 A1, 2004 ;
Location in patent: Page 20 ;
US 20040054186 A1
