1,2,4,5-四甲氧基苯合成路线 （共 37 条）
反应条件
1: 2,4,5-trimethoxyphenol With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 0.5 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=20°C; 13 h;
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZONA STATE UNIVERSITY; MADATHIL, Manikandadas, Mathilakathu; KHDOUR, Omar; HECHT, Sidney
Patent: WO2014/59158 A1, 2014 ;
Location in patent: Page/Page column 34 ;
反应条件
1: 2,5-dimethoxy-1,4-benzoquinone With potassium hydroxide in dimethyl sulfoxide T=20°C; 0.333333 h; 2: methyl iodide in dimethyl sulfoxide
参考文献
Chen, Fanglei; Zhang, Guiping; Hong, Zebin; Lin, Zhonghui; Lei, Min; Huang, Mingdong; Hu, Lihong
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2379 - 2382
反应条件
sodium hydrogensulfite; sodium hydroxide in ethanol; water T=80°C; 36.5 h; Cooling with ice;
参考文献
Hanss, David; Walther, Mathieu E.; Wenger, Oliver S.
Chemical Communications, 2010 , vol. 46, # 37 p. 7034 - 7036
反应条件
methanol; potassium hydroxide; aluminium amalgam anschliessend Kochen mit Dimethylsulfat;
参考文献
Sato, Hideaki; Guengerich, F. Peter
Journal of the American Chemical Society, 2000 , vol. 122, # 33 p. 8099 - 8100
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Wessig, Pablo; Moellnitz, Kristian
Journal of Organic Chemistry, 2008 , vol. 73, # 12 p. 4452 - 4457
反应条件
1: methanol / 20 - 22 °C 2: PbO2 / 20 - 22 °C 3: 96 percent / H2SO4 / methanol 4: 5.50 mg / NaBH4 / ethanol / 3 h / 0 °C 5: 4.9 mg / NaOH; NaHSO3 / ethanol / 4 h / 70 - 80 °C View Scheme
参考文献
Stahl; Kissau; Mazitschek; Huwe; Furet; Giannis; Waldmann
Journal of the American Chemical Society, 2001 , vol. 123, # 47 p. 11586 - 11593
反应条件
1: 96 percent / H2SO4 / methanol 2: 5.50 mg / NaBH4 / ethanol / 3 h / 0 °C 3: 4.9 mg / NaOH; NaHSO3 / ethanol / 4 h / 70 - 80 °C View Scheme
参考文献
Stahl; Kissau; Mazitschek; Huwe; Furet; Giannis; Waldmann
Journal of the American Chemical Society, 2001 , vol. 123, # 47 p. 11586 - 11593
反应条件
1: PbO2 / 20 - 22 °C 2: 96 percent / H2SO4 / methanol 3: 5.50 mg / NaBH4 / ethanol / 3 h / 0 °C 4: 4.9 mg / NaOH; NaHSO3 / ethanol / 4 h / 70 - 80 °C View Scheme
参考文献
Stahl; Kissau; Mazitschek; Huwe; Furet; Giannis; Waldmann
Journal of the American Chemical Society, 2001 , vol. 123, # 47 p. 11586 - 11593
反应条件
sodium hydroxide in water; acetone 2 h; Ambient temperature;
参考文献
Cole, Edward R.; Crank, George; Minh, H. T. Hai
Australian Journal of Chemistry, 1980 , vol. 33, # 3 p. 527 - 543
反应条件
1: mCPBA / 2 h / Ambient temperature 2: aq. KOH / ethanol / 2 h / 50 °C 3: 94 percent / NaH / dimethylformamide / 1 h / Ambient temperature View Scheme
参考文献
Filosa, Rosanna; Peduto, Antonella; Aparoy, Polamarasetty; Schaible, Anja M.; Luderer, Susann; Krauth, Verena; Petronzi, Carmen; Massa, Antonio; De Rosa, Mario; Reddanna, Pallu; Werz, Oliver
European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 269 - 279
