2-(3-溴丙基)-2-甲基-1,3-二氧戊环合成路线 （共 27 条）
反应条件
1: 2.) 30percent sodium hydroxide / 1.) toluene, reflux, 2 d; 2.) water, reflux 2h 2: 41 percent / butyl-lithium / tetrahydrofuran / 1.) -78 degC, 4 h, 2.) -78 degC to R. T. 3: 85 percent / m-chloroperbenzoic acid / CHCl3 / 2 h / Ambient temperature 4: 95 percent / toluene / 6 h / 100 °C 5: 75 percent / 1.) butyl-lithium, 2.) benzaldehyde, H2O / tetrahydrofuran / 1.) -60 degC, 2.) -78 degC to R. T. View Scheme
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
1.1: Na; NH3; Fe(NO3)3*9H2O / 1 h / Heating 1.2: 47 percent / tetrahydrofuran / 1.5 h / -33 °C 2.1: 61 percent / oxalic acid; H2O / acetone / 2.5 h / Heating View Scheme
参考文献
Vasil'ev; Serebryakov
Russian Journal of Organic Chemistry, 1998 , vol. 34, # 7 p. 981 - 984
反应条件
1: 2.) 30percent sodium hydroxide / 1.) toluene, reflux, 2 d; 2.) water, reflux 2h 2: 18 percent / 50percent sodium hydride / dimethylformamide / 1 h / 50 °C View Scheme
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
1: 78 percent / LiBr, TMSCl / acetonitrile / 15 h / Heating
2: 96 percent / p-TsOH / benzene / 5 h / Heating
View Scheme
参考文献
Joubert; Beney; Marsura; Luu-Duc
Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 8 p. 745 - 754
反应条件
ethyl bromide; sodium bromide in various solvent(s)
T=65°C; 72 h;
参考文献
Pastouret, A.; Vidal, J. P.; Durand, T.; Girard, J. P.; Rossi, J. C.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, # 2 p. 206 - 213
反应条件
toluene-4-sulfonic acid; orthoformic acid triethyl ester
T=20°C; 25 h;
参考文献
Audin, Patrick; Doutheau, Alain; Gore, Jacques
Bulletin de la Societe Chimique de France, 1984 , vol. 2, # 7-8 p. 297 - 306
反应条件
1: 80 percent / HBr / H2O / Heating
2: 80 percent / p-TsOH / benzene / Heating
View Scheme
参考文献
Wu, Jin-Ming; Li, Ying
Tetrahedron Letters, 2001 , vol. 42, # 38 p. 6737 - 6739
反应条件
sodium bromide in N,N-dimethyl-formamide
T=65°C; 2 h; Yield given;
参考文献
Odinokov, V. N.; Ishmuratov, G. Yu.; Kharisova, R. Ya.; Vakhidov, R. R.; Botsman, L. P.; Tolstikov, G. A.
Chemistry of Natural Compounds, 1993 , vol. 29, # 2 p. 240 - 244
Khimiya Prirodnykh Soedinenii, 1993 , # 2 p. 288 - 292
反应条件
1: LiAlH4
2: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
3: LiBr / acetone / 1.) room temperature, overnight, 2.) reflux, 4 h
View Scheme
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
反应条件
2: LiAlH4
3: 100 percent / Et3N / CH2Cl2 / 2 h / 0 - 5 °C
4: LiBr / acetone / 1.) room temperature, overnight, 2.) reflux, 4 h
View Scheme
参考文献
Joshi, Navalkishore N.; Mamdapur, Vasant R.; Chadha, Mohindra S.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2963 - 2966
