2,4-二甲基吡咯-3,5-二羧酸二乙酯合成路线 （共 64 条）
反应条件
1: 42 percent / bromine / acetic acid / 0.5 h / 40 - 43 °C 2: 50 percent / aq. HBr / methanol / 7 h / Heating 3: NaOH / ethanol; H2O / 3 h / Heating 4: 120 h / 210 - 220 °C View Scheme
参考文献
Byun; Lightner
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1683 - 1692
反应条件
1: bromine; SO2Cl2; acetic acid / Reagens 4: Acetanhydrid; anschliessend Behandeln mit H2O 2: acetic acid; bromine 3: palladium/charcoal / magnesium oxide catalyst; methanol / Hydrogenation View Scheme
参考文献
Corwin et al.
Journal of the American Chemical Society, 1942 , vol. 64, p. 1267,1271
反应条件
potassium hydroxide in ethylene glycol T=160°C; 4 h;
参考文献
Organic Letters, , vol. 13, # 17 p. 4490 - 4493
参考文献
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 132, p. 98
参考文献
Justus Liebigs Annalen der Chemie, , vol. 236, p. 296,298
Chemische Berichte, , vol. 22, p. 162
反应条件
acetic acid; paraformaldehyde
参考文献
Canadian Patents and Development Limited
Patent: US4070366 A1, 1978 ;
反应条件
sodium methylate T=200 - 235°C; im Rohr;
参考文献
Colacicchi; Bertoni
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1912 , vol. <5> 21 I, p. 654,656
反应条件
T=215 - 225°C; im Rohr;
参考文献
Colacicchi; Bertoni
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1912 , vol. <5> 21 I, p. 654,656
反应条件
sulfuryl dichloride; chloroform Reaktion ueber mehrere Stufen;
参考文献
Lichtenwald
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1942 , vol. 273, p. 118,127
反应条件
1: concentrated aqueous KOH-solution / 160 °C 2: hydrogen chloride View Scheme
参考文献
Corwin; Krieble
Journal of the American Chemical Society, 1941 , vol. 63, p. 1829,1831
