hydrogenchloride

diethyl ether

暂无反应条件数据

lithium diisopropyl amide 1.) THF, HMPT, from -90 to -80 deg C, 5 min, 2.) THF, HMPT, from -80 deg C to RT, 1.5 h;

1.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 2 h / -73 - -10 °C / Inert atmosphere 1.2: 16 h / -70 - 20 °C 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 15 - 20 °C 2.2: 10 °C / pH ~ 4 3.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 2 h / 10 - 110 °C 3.2: 40 h / 110 °C 4.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / methanol / 10 h / 1551.49 Torr View Scheme