(S)-2-羟基-3-甲基丁酸甲酯合成路线 （共 22 条）
反应条件
sulfuric acid 3 h; Heating;
参考文献
Ewing, William R.; Harris, Bruce D.; Li, Wen-Ren; Joullie, Madeleine M.
Tetrahedron Letters, 1989 , vol. 30, # 29 p. 3757 - 3760
反应条件
thionyl chloride T=-30 - 20°C; 48.25 h;
参考文献
Poterala, Marcin; Plenkiewicz, Jan
Tetrahedron Asymmetry, 2011 , vol. 22, # 3 p. 294 - 299
反应条件
methanol; chloro-trimethyl-silane
参考文献
Tranzyme Pharma Inc.
Patent: US2008/194672 A1, 2008 ;
Location in patent: Page/Page column 49-50 ;
US 20080194672 A1
反应条件
tetrafluoroboric acid; hydrogen; [Ru(R)-Binap(benzene)Cl]Cl in methanol T=30°C; P=76000 Torr; 70 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Mashima, Kazushi; Kusano, Koh-hei; Sato, Naomasa; Matsumura, Yoh-ichi; Nozaki, Kyoko; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3064 - 3076
反应条件
1: NaNO2; H2SO4 / H2O / 24 h / 0 °C 2: p-toluenesulfonic acid monohydrate / methanol / 24 h / 45 °C View Scheme
参考文献
Hasuoka, Atsushi; Nishikimi, Yuji; Nakayama, Yutaka; Kamiyama, Keiji; Nakao, Masafumi; Miyagawa, Ken-Ichiro; Nishimura, Osamu; Fujino, Masahiko
Journal of Antibiotics, 2002 , vol. 55, # 3 p. 322 - 336
反应条件
in diethyl ether T=0°C;
参考文献
Koch, Patrick; Nakatani, Yoichi; Luu, Bang; Ourisson, Guy
Bulletin de la Societe Chimique de France, 1983 , vol. 2, # 7/8 p. 185 - 194
反应条件
potassium 9-O-(1,2:5,6-di-O-isopropylidene-α-D-glucofuranosyl)-9-boratabicyclolt;3.3.1gt;nonane in tetrahydrofuran T=-78°C; 8 h;
参考文献
Brown, Herbert C.; Cho, Byung Tae; Park, Won Suh
Journal of Organic Chemistry, 1988 , vol. 53, # 6 p. 1231 - 1238
反应条件
1: lyngbyabellin M With ozone in dichloromethane T=-78°C; 0.0833333 h; 2: With hydrogenchloride; water in dichloromethane T=110°C; 2 h; 3: diazomethane in dichloromethane T=20°C; 0.5 h;
参考文献
Choi, Hyukjae; Mevers, Emily; Byrum, Tara; Valeriote, Frederick A.; Gerwick, William H.
European Journal of Organic Chemistry, 2012 , # 27 p. 5141 - 5150
反应条件
potassium carbonate in acetone 1.) room temperature, 1 h, 2.) reflux, overnight; Yield given;
参考文献
Hoffman, Robert V.; Tao, Junhua
Journal of Organic Chemistry, 1997 , vol. 62, # 7 p. 2292 - 2297
反应条件
1: 65 percent / Et3N, DMAP / CH2Cl2 / 6 h / Ambient temperature 2: 75 percent / HCl / tetrahydrofuran; H2O / 3 h / Ambient temperature 3: KBH4 / methanol / 10 h / 0 °C 4: 54 percent / H2SO4 / H2O / 0.5 h / 90 °C 5: 72 percent View Scheme
参考文献
Pansare, Sunil V.; Ravi, R. Gnana
Tetrahedron, 1998 , vol. 54, # 48 p. 14549 - 14564
