6-氨基-1-甲基尿嘧啶合成路线 （共 36 条）
反应条件
1: NaNO2, AcOH / H2O / 2 h / Ambient temperature 2: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C 3: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 8 p. 653 - 658
反应条件
bromine; sodium acetate in acetic acid T=20 - 125°C;
参考文献
Balssa, Frederic; Bonnaire, Yves
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 1 p. 33 - 41
参考文献
Barker; Luthy
Journal of the Chemical Society, 1956 , p. 917,920
参考文献
Justus Liebigs Annalen der Chemie, , vol. 340, p. 312
反应条件
1: ethanol; water; NaOH 2: ethanol / und beim aufeinanderfolgenden Erwaermen mit Zink und wss.Ameisensaeure, mit Formamid und mit wss.NaOH View Scheme
参考文献
Satoda et al.
Yakugaku Kenkyu, 1956 , vol. 28, p. 609,611, 612
Chem.Abstr., 1957 , p. 16483
反应条件
1: 83 percent / sodium acetate trihydrate, Br2 / acetic acid / 2 h / from 90 deg C to 20 deg C 2: 57 percent / 3 h / 65 °C View Scheme
参考文献
Rybar, Alfonz; Hesek, Dusan; Szemes, Fridrich; Alfoeldi, Juraj; Tegza, Marian
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 9 p. 2257 - 2269
反应条件
1: 61 percent / 1percent aq. NaOH, sodium nitromalonaldehyde / 2 h / 80 °C 2: 59 percent / 0.05 N aq. NaOH / methanol / 1 h / Ambient temperature 3: 84 percent / H2, AcOH / 5percent Pd/C / ethanol; acetic acid View Scheme
参考文献
Heterocycles, , vol. 33, # 2 p. 905 - 929
反应条件
1.1: 33 percent / 10percent aq. NaOH / methanol / 3 h / Heating 2.1: 50 percent / NaNO2; 6N HCl; AcOH / 0.17 h 3.1: Na2S2O4 / ethyl acetate; H2O 3.2: 44 percent / 2 h / Heating View Scheme
参考文献
Kim, Soon-Ai; Marshall, Melissa A.; Melman, Neli; Kim, Hak Sung; Mueller, Christa E.; Linden, Joel; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2131 - 2138
反应条件
1: sodium nitrite / acetic acid; water
2: sodium dithionite; ammonium hydroxide
3: water
View Scheme
参考文献
Lin, Kuaile; Cai, Zhengyan; Wang, Fei; Zhang, Wei; Zhou, Weicheng
Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 4 p. 477 - 482
反应条件
1: 99.5 percent / sodium acetate trihydrate; bromine / acetic acid / 20 - 125 °C
2: 62 percent / 2 h / 100 °C
View Scheme
参考文献
Rybar, Alfonz; Hesek, Dusan; Szemes, Fridrich; Alfoeldi, Juraj; Tegza, Marian
Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 9 p. 2257 - 2269
