1,4-二氢-3(2H)-异喹啉酮合成路线 （共 37 条）
反应条件
1: 8 percent / p-toluenesulfonic acid / CCl4 / 0.33 h / Heating 2: 86 percent / Raney nickel / ethanol / 2 h / Heating View Scheme
参考文献
Synthesis, , # 7 p. 534 - 537
反应条件
1: 81 percent / triethylamine / CH2Cl2 / 0.5 h / Ambient temperature 2: 87 percent / 3-chlorobenzoperoxoic acid / CH2Cl2 / 1.) 0 deg C, 2.) room temp., 1 h 3: 8 percent / p-toluenesulfonic acid / CCl4 / 0.33 h / Heating 4: 86 percent / Raney nickel / ethanol / 2 h / Heating View Scheme
参考文献
Synthesis, , # 7 p. 534 - 537
反应条件
(S)-pyrophosphoric acid T=140 - 160°C; 1 h;
参考文献
Watanabe, Yasuo; Kamochi, Yasoko; Miyazaki, Tokumitsu
Heterocycles, 1981 , vol. 16, # 4 p. 609 - 611
反应条件
1: 1.) sec-BuLi / 1.) THF, cyclohexane, -35 deg C, 2.) THF, cyclohexane 2: 70 percent / HCl / ethanol View Scheme
参考文献
Heterocycles, , vol. 32, # 9 p. 1699 - 1703
参考文献
Yakugaku Zasshi, , vol. 79, p. 1578,1581
Chem.Abstr., , p. 11025
反应条件
hydrogenchloride; sodium carbonate 1) THF, 2) THF; Multistep reaction;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 17 p. 1165 - 1166
反应条件
ueber den Schmelzpunkt;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 445, p. 246
反应条件
unter vermindertem Druck;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 445, p. 246
反应条件
1: 64 percent / CH2Cl2 / 48 h / 25 °C 2: 1) n-BuLi / 1) hexane, THF, -70 deg C, 15 min, 2a) -70 deg C, 1 h, b) r t., 10 min 3: 1) n-BuLi / 1) hexane, THF, -70 deg C, 15 min, 2) -40 deg C, 15 h 4: N(Et)3 / CH2Cl2 / 0.25 h / -5 °C 5: 23 percent / KOtBu / dimethylsulfoxide / 0.5 h / other 1,4-dihydroquinolinemesylates; conversion of 1,4-dihydroquinolines to 2-benzazepines View Scheme
参考文献
Groth, Ulrich; Richter, Lutz; Schoellkopf, Ulrich; Zindel, Juergen
Liebigs Annalen der Chemie, 1992 , # 11 p. 1179 - 1184
反应条件
1: 64 percent / CH2Cl2 / 48 h / 25 °C 2: 1) n-BuLi / 1) hexane, THF, -70 deg C, 15 min, 2a) -70 deg C, 1 h, b) r t., 10 min 3: 1) n-BuLi / 1) hexane, THF, -70 deg C, 15 min, 2a) -70 deg C, 1 h, b) 25 deg C, 10 min 4: 67 percent / NaBH4 / ethanol / 4 h / 25 °C 5: N(Et)3 / CH2Cl2 / 0.25 h / -5 °C 6: 63 percent / KOtBu / dimethylsulfoxide / 0.5 h View Scheme
参考文献
Liebigs Annalen der Chemie, , # 11 p. 1179 - 1184
