N-苄氧羰基-L-alpha-氨基己二酸合成路线 （共 16 条）
反应条件
sodium hydroxide in water Cooling with ice;
参考文献
Hachisako, Hiroshi; Ryu, Naoya; Murakami, Ryoichi
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 11 p. 2327 - 2337
反应条件
sodium hydroxide; potassium permanganate T=5 - 10°C; 2 h;
参考文献
Szirtes, Tamas; Kisfaludy, Lajos; Palosi, Eva; Szporny, Laszlo
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1654 - 1658
反应条件
silver benzoate; triethylamine in tetrahydrofuran; water 0.5 h; Ambient temperature;
参考文献
Pellicciari, Roberto; Natalini, Benedetto; Marinozzi, Maura
Synthetic Communications, 1988 , vol. 18, # 14 p. 1707 - 1714
反应条件
hydrogenchloride; sodium carbonate
参考文献
Zeneca Limited; British Technology Group Ltd.
Patent: US5789417 A1, 1998 ;
参考文献
Mori, Kenji; Sugai, Takeshi; Maeda, Yukari; Okazaki, Tomomi; Noguchi, Tadashi; Naito, Hiroshi
Tetrahedron, 1985 , vol. 41, # 22 p. 5307 - 5312
反应条件
2: N-methylmorpholine / CH2Cl2 / 0.25 h / -10 °C 3: CH2Cl2; diethyl ether / 0 deg C, 30 min, -5 deg C, 4 h 4: 99 percent / PhCO2Ag, Et3N / tetrahydrofuran; H2O / 0.5 h / Ambient temperature View Scheme
参考文献
Pellicciari, Roberto; Natalini, Benedetto; Marinozzi, Maura
Synthetic Communications, 1988 , vol. 18, # 14 p. 1707 - 1714
反应条件
1: N-methylmorpholine / CH2Cl2 / 0.25 h / -10 °C 2: CH2Cl2; diethyl ether / 0 deg C, 30 min, -5 deg C, 4 h 3: 99 percent / PhCO2Ag, Et3N / tetrahydrofuran; H2O / 0.5 h / Ambient temperature View Scheme
参考文献
Pellicciari, Roberto; Natalini, Benedetto; Marinozzi, Maura
Synthetic Communications, 1988 , vol. 18, # 14 p. 1707 - 1714
反应条件
1: 84 percent / aq. NaOH, aq. Na2CO3 / 3 h / 0 - 5 °C 2: 82 percent / aq. NaOH, KMnO4 / 2 h / 5 - 10 °C View Scheme
参考文献
Szirtes, Tamas; Kisfaludy, Lajos; Palosi, Eva; Szporny, Laszlo
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1654 - 1658
反应条件
1: 84 percent / aq. NaOH, aq. Na2CO3 / 3 h / 0 - 5 °C 2: 82 percent / aq. NaOH, KMnO4 / 2 h / 5 - 10 °C View Scheme
参考文献
Szirtes, Tamas; Kisfaludy, Lajos; Palosi, Eva; Szporny, Laszlo
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1654 - 1658
反应条件
Nα-(benzyloxycarbonyl)aminoadipic acid-δ-semialdehyde dehydrogenase from Rhodococcus sp. AIU Z-35-1; Reduced nicotinamide-adenine dinucleotide T=30°C; pH=7; aq. phosphate bufferEnzymatic reaction;
参考文献
Isobe, Kimiyasu; Fukuda, Nahoko; Nagasawa, Shouko; Saitou, Kaoru
Chemistry and Biodiversity, 2010 , vol. 7, # 6 p. 1549 - 1554
