5,5-双(羟甲基)-2-苯基-1,3-二氧杂环己烷合成路线 （共 14 条）
反应条件
1: 2,2-bis(hydroxymethyl)-1,3-propanediol in water T=60°C; 2: benzaldehyde With hydrogenchloride in water T=25°C; 3 h;
参考文献
Journal of the American Chemical Society, , vol. 135, # 24 p. 9055 - 9077
反应条件
hydrogenchloride T=25°C;
参考文献
Journal of Chemical Research, Miniprint, , # 1 p. 111 - 128
反应条件
1: 81 percent / pyridine / 10 h / Ambient temperature 2: 1.) NaH, 2.) KI / 1.) DMF, 70 deg C, 30 min, 2.) DMF, 140 deg C, 12 h View Scheme
参考文献
Pecquet, Pascal; Huet, Francois; Legraverend, Michel; Bisagni, Emile
Heterocycles, 1992 , vol. 34, # 4 p. 739 - 745
反应条件
sodium hydride in tetrahydrofuran T=20°C; Methylation;
参考文献
Heinonen, Petri; Virta, Pasi; Loennberg, Harri
Tetrahedron, 1999 , vol. 55, # 24 p. 7613 - 7624
反应条件
pyridine; thionyl chloride; chloroform Erhitzen des Reaktionsprodukts mit Dioxan enthaltender wss.Salzsaeure.;
参考文献
Wawzonek; Issidorides
Journal of the American Chemical Society, 1953 , vol. 75, p. 2373
反应条件
pyridine
10 h; Ambient temperature;
参考文献
Pecquet, Pascal; Huet, Francois; Legraverend, Michel; Bisagni, Emile
Heterocycles, 1992 , vol. 34, # 4 p. 739 - 745
反应条件
1: 81 percent / pyridine / 10 h / Ambient temperature
2: 1.) NaH, 2.) KI / 1.) DMF, 70 deg C, 30 min, 2.) DMF, 140 deg C, 12 h
3: 92 percent / KOH
4: 94 percent / HNO3
View Scheme
参考文献
Pecquet, Pascal; Huet, Francois; Legraverend, Michel; Bisagni, Emile
Heterocycles, 1992 , vol. 34, # 4 p. 739 - 745
反应条件
1: 77 percent / pyridine
2: 731 mg / H2O / 3 h / 90 °C
View Scheme
参考文献
David, Serge
Carbohydrate Research, 2001 , vol. 331, # 3 p. 327 - 329
反应条件
1: 37 percent / NaH / dimethylsulfoxide / 70 h / 50 °C
2: 77 percent / 1 N aq. HCl / tetrahydrofuran / 4 h / Heating
View Scheme
参考文献
Ouchi, Mikio; Inoue, Yoshihisa; Sakamoto, Hidefumi; Yamahira, Atsushi; Yoshinaga, Masanobu; Hakushi, Tadao
Journal of Organic Chemistry, 1983 , vol. 48, # 19 p. 3168 - 3173
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in toluene
T=20°C; 16 h;
2: With potassium tert-butylate
参考文献
Behrendt, Jonathan M.; Bala, Kason; Golding, Peter; Hailes, Helen C.
Tetrahedron Letters, 2005 , vol. 46, # 4 p. 643 - 645
