2,6-二甲基-4-硝基苯酚合成路线 （共 35 条）
参考文献
Jones; Kenner
Journal of the Chemical Society, 1931 , p. 1842,1850
参考文献
Jones; Kenner
Journal of the Chemical Society, 1931 , p. 1842,1850
反应条件
phosphorus pentachloride; phenol 1.) 140 deg C, 1 h, 2.) 215 deg C, 45 min;
参考文献
Wright, Stephen W.
Organic Preparations and Procedures International, 1997 , vol. 29, # 1 p. 128 - 131
反应条件
1: water; ammonia / 180 °C 2: Diazotization.Behandlung der Diazoniumsalz-Loesung mit CuBr 3: tin (II)-chloride; aq.-ethanolic hydrochloric acid View Scheme
参考文献
Spitzer; Wheland
Journal of the American Chemical Society, 1940 , vol. 62, p. 2995,3001
反应条件
1: ethanolic sodium ethylate 2: Raney nickel; diethyl ether / Hydrogenation View Scheme
参考文献
Bruice et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 83,87
反应条件
hydrogen; platinum(IV) oxide in methanol P=2585.81 Torr; 24 h;
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; GERSHENGORN, Marvin; NEUMANN, Susanne; HUANG, Wenwei; THOMAS, Craig, J.
Patent: WO2011/127388 A2, 2011 ;
Location in patent: Page/Page column 53-55 ;
WO 2011/127388 A2
反应条件
(i) SnCl2, HCl, EtOH, (ii) /BRN= 385737/, AcOH; Multistep reaction;
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
反应条件
1: pyridine / dichloromethane / 3.33 h / 0 °C 2: cesium fluoride / N,N-dimethyl-formamide / 16 h / |Reflux View Scheme
参考文献
Chemical Communications, , vol. 49, # 21 p. 2151 - 2153
反应条件
hydrogenchloride; tin; acetic acid 48 h;
参考文献
Johnson, Steven M.; Connelly, Stephen; Wilson, Ian A.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 20 p. 6348 - 6358
