甲基N-[(苄氧基)羰基]-L-缬氨酸酯合成路线 （共 35 条）
反应条件
Amberlite XAD-8; immobilized papain (Carica papaya) in ethyl acetate T=37°C; 12 h; pH=5.0;
参考文献
Chen, Shui-Tein; Wang, Kung Tsung
Journal of the Chemical Society, Chemical Communications, 1988 , # 4 p. 327 - 328
反应条件
1: carbon dioxide; (L)-valine methyl ester hydrochloride With tetra-(n-butyl)ammonium iodide; caesium carbonate in N,N-dimethyl-formamide T=23°C; 1 h; 2: benzyl chloride in N,N-dimethyl-formamide T=23°C; 24 h;
参考文献
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Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 1035 - 1037
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Salvatore; Seung Il Shin; Nagle; Kyung Woon Jung
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 1035 - 1037
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C; 1 h;
参考文献
Sakaitani, Masahiro; Ohfune, Yasufumi
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 870 - 876
反应条件
4 A molecular sieve in diethyl ether T=0°C; 22 h; Title compound not separated from byproducts.;
参考文献
Hang; Tian; Tang; Deng
Journal of the American Chemical Society, 2001 , vol. 123, # 50 p. 12696 - 12697
反应条件
1: methanol; 2-aminoisovaleric acid With chloro-trimethyl-silane T=0 - 20°C; 2: benzyl chloroformate With pyridine T=20°C; 12 h;
参考文献
Hernandez, J. Nicolas; Martin, Victor S.
Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3590 - 3592
反应条件
1: NMM / tetrahydrofuran / -25 - 20 °C 2: 20 percent mol DHQD-PHN; 4 Angstroem molecular sieves / diethyl ether / 22 h / 0 °C View Scheme
参考文献
Hang; Tian; Tang; Deng
Journal of the American Chemical Society, 2001 , vol. 123, # 50 p. 12696 - 12697
反应条件
1: (L)-valine methyl ester hydrochloride With N-ethyl-N,N-diisopropylamine in dichloromethane T=0°C; 0.25 h; Inert atmosphere; 2: benzyl chloroformate in dichloromethane T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Bai, Wen-Ju; Jackson, Stephen K.; Pettus, Thomas R. R.
Organic Letters, 2012 , vol. 14, # 15 p. 3862 - 3865
反应条件
in tetrahydrofuran T=30°C; 6 h;
参考文献
Anbazhagan, Mariappan; Reddy, T. Indrasena; Rajappa, Srinivasachari
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 11 p. 1623 - 1627
反应条件
1: 100 percent / triethylamine / Pd(OAc)2 / CH2Cl2 / 8 h / Ambient temperature 2: 85 percent / n-Bu4NF / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Sakaitani, Masahiro; Ohfune, Yasufumi
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 870 - 876
参考文献
Sankyo Company Limited
Patent: US3937718 A1, 1976 ;
