1: With n-butyllithium; zirconocene dichloride in tetrahydrofuran; hexane T=-78 - 20°C; 2: With CuCl*2LiCl in tetrahydrofuran; hexane T=45°C; 1 h; 3: With N-bromosuccinmide in tetrahydrofuran; hexane Further stages.;

tris(dibenzylideneacetone)dipalladium (0) in toluene T=100°C; Stille reaction; 20 h;

[Pd{bis[2-(diphenylphosphino)phenyl] ether}Cl2] in tetrahydrofuran T=20°C;

1: triphenyl-methyl-phosphonium iodide With n-butyllithium in tetrahydrofuran; Petroleum ether T=-40°C; 0.833333 h; 2: α-bromocinnamaldehyde in tetrahydrofuran; Petroleum ether T=20°C; 1 h; Further stages.;

tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Substitution; 1 h;

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: tetrahydrofuran; hexane / 1 h / -78 °C 1.3: tetrahydrofuran; hexane / -78 - 20 °C 2.1: aq. KOH / tetrahydrofuran; hexane / 2 h 3.1: n-Bu2ZrCp2 / tetrahydrofuran; hexane / -78 - 20 °C 3.2: CuCl; LiCl / tetrahydrofuran; hexane / 1 h / 45 °C 3.3: 58 percent / NBS / tetrahydrofuran; hexane / 0 °C View Scheme

1: 99 percent / t-BuOK / hexane / 0 - 20 °C 2: dimethylformamide / 0.25 h / 150 °C View Scheme

暂无反应条件数据

T=180°C; P=90 Torr; other alkyl-substituted 1,1-dibromo-2-phenylcyclopropanes; Product distribution;

in methanol T=20°C; Irradiation; Yield given. Further byproducts given. Yields of byproduct given;