2’-溴-4-氯苯乙酸甲酯合成路线 （共 12 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane 5 h; Heating;
参考文献
Sweeney; Tavassoli, Ali; Carter, Neil B.; Hayes, Jerome F.
Tetrahedron, 2002 , vol. 58, # 51 p. 10113 - 10126
反应条件
1: 93 percent / conc. sulfuric acid / 3 h / Heating 2: 96 percent / N-bromosuccinimide; azobisisobutyronitrile / CCl4 / 5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 51 p. 10113 - 10126
反应条件
1: (4-chloro-phenyl)-acetic acid With thionyl chloride T=55°C; 1 h; 2: With bromine T=9 - 80°C; 23.3333 h; 3: methanol
参考文献
METABOLEX, INC.
Patent: WO2006/102375 A2, 2006 ;
Location in patent: Page/Page column 70 ;
WO 2006/102375 A2
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 24 p. 4783 - 4803
反应条件
thionyl bromide in toluene T=20°C; Bromination;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 900 - 910
反应条件
hydrogen bromide 3 h; Heating;
参考文献
Robert, A.; Jaguelin, S.; Guinamant, J. L.
Tetrahedron, 1986 , vol. 42, # 8 p. 2275 - 2282
反应条件
1: H2SO4 / Heating 2: SOBr2 / toluene / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 900 - 910
反应条件
1: aq. KOH; LiCl / dioxane / 10 - 15 °C 2: H2SO4 / Heating 3: SOBr2 / toluene / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 5 p. 900 - 910
反应条件
1: 98 percent / 2.5 N sodium hypochlorite, 2 N sulfuric acid / acetonitrile / 0.5 h / Ambient temperature 2: 85 percent / 48percent hydrobromic acid / 3 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 42, # 8 p. 2275 - 2282
反应条件
bromine anschliessend mit Methanol umsetzen;
参考文献
Journal of the Chemical Society, , p. 1542,1548
