4-羟基-3-羟甲基苯乙酮二乙酸酯合成路线 （共 9 条）
反应条件
sodium acetate; acetic anhydride in water; acetic acid
参考文献
Imperial Chemical Industries Limited
Patent: US4423070 A1, 1983 ;
反应条件
1: formaldehyd; 4-hydroxy-acetophenone With resin-bound piperazinomethylpolystyrene in tetrahydrofuran; water 2: acetic anhydride With toluene-4-sulfonic acid in toluene T=110°C; Further stages.;
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
resin-SO3H in toluene T=80°C;
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
sodium acetate; acetic acid
参考文献
Collin; Hartley; Jack; Lunts; Press; Ritchie; Toon
Journal of medicinal chemistry, 1970 , vol. 13, # 4 p. 674 - 680
反应条件
polyvinylpyridinium bromide perbromide resin in dichloromethane
参考文献
Imperial Chemical Industries Limited
Patent: US4423070 A1, 1983 ;
反应条件
1: polyvinylpyridinium bromide perbromide resin / CH2Cl2 2: 1N HBr / tetrahydrofuran / 75 °C 3: resin-SO3H / CH2Cl2 View Scheme
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
(i) Br2, (ii) /BRN= 507464/; Multistep reaction;
参考文献
Collin; Hartley; Jack; Lunts; Press; Ritchie; Toon
Journal of medicinal chemistry, 1970 , vol. 13, # 4 p. 674 - 680
反应条件
1: polyvinylpyridinium bromide perbromide resin / CH2Cl2
2: 1N HBr / tetrahydrofuran / 75 °C
View Scheme
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
1: 3-(acetoxymethyl)-4-acetoxyacetophenone With bromine
0.5 h; Heating / reflux;
2: N-benzyl-t-butylamine 20 - 25 h; Heating / reflux;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US2005/9926 A1, 2005 ;
Location in patent: Page 2-3 ;
