2,2,6-三甲基环己酮合成路线 （共 96 条）
参考文献
Haller
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1913 , vol. 157, p. 180
反应条件
diethyl ether; sodium amide
参考文献
Haller; Cornubert
Bulletin de la Societe Chimique de France, 1927 , vol. <4> 41, p. 367
反应条件
sodium amide; benzene
参考文献
Haller; Cornubert
Bulletin de la Societe Chimique de France, 1927 , vol. <4> 41, p. 367
反应条件
Behandeln mit Methyljodid;
参考文献
Haller
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1913 , vol. 157, p. 180
反应条件
2: CuSO4*3H2O / xylene / Heating
View Scheme
参考文献
Julia,M.; Descoins,C.
Bulletin de la Societe Chimique de France, 1962 , p. 1939 - 1947
反应条件
1: sodium bisulphate / H2O / 6 h / 0 - 15 °C
2: SOCl2, pyridine / benzene / 1 h / Heating
3: 1.8548 g / benzoyl peroxide, N-bromosuccinimide / CCl4 / 0.67 h / Heating
4: 27 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 4 h / Heating
View Scheme
参考文献
Kutney, James P.; Gunning, Philip J.; Clewley, Robin G.; Somerville, John; Rettig, Steven J.
Canadian Journal of Chemistry, 1992 , vol. 70, # 7 p. 2094 - 2114
反应条件
1: 2,6,6-trimethyl-cyclohexan-1-one With lithium hexamethyldisilazane in tetrahydrofuran
T=0°C; 1 h;
2: chloroformic acid allyl ester in tetrahydrofuran
T=-78°C;
参考文献
McFadden, Ryan M.; Stoltz, Brian M.
Journal of the American Chemical Society, 2006 , vol. 128, # 24 p. 7738 - 7739
反应条件
1: 2,6,6-trimethyl-cyclohexan-1-one With lithium diisopropyl amide in tetrahydrofuran
T=-78 - 0°C; 1 h;
2: Mander's reagent With N,N,N',N',N'',N''-hexamethylphosphoric triamide in tetrahydrofuran
T=-78 - 20°C;
参考文献
Mohr, Justin T.; Behenna, Douglas C.; Harned, Andrew M.; Stoltz, Brian M.
Angewandte Chemie - International Edition, 2005 , vol. 44, # 42 p. 6924 - 6927
反应条件
1.1: Br2
1.2: pyridine / Heating
2.1: 88 percent / tetrahydrofuran / Heating
3.1: 54 percent / P2O5; Celite / toluene / Heating
4.1: 78 percent / KOH
View Scheme
参考文献
Puglisi, Carolyn J; Elsey, Gordon M; Prager, Rolf H; Skouroumounis, George K; Sefton, Mark A
Tetrahedron Letters, 2001 , vol. 42, # 39 p. 6937 - 6939
反应条件
potassium permanganate
参考文献
Masson
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1912 , vol. 154, p. 518
