2,2,6-三甲基环己酮合成路线 （共 96 条）
反应条件
1: sodium bisulphate / H2O / 6 h / 0 - 15 °C 2: SOCl2, pyridine / benzene / 1 h / Heating View Scheme
参考文献
Kutney, James P.; Gunning, Philip J.; Clewley, Robin G.; Somerville, John; Rettig, Steven J.
Canadian Journal of Chemistry, 1992 , vol. 70, # 7 p. 2094 - 2114
反应条件
sodium tetrahydroborate in methanol; water
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 11 p. 2191 - 2194
反应条件
hydrogenchloride; chiral LiN(CH(CH3)Ph)2 Multistep reaction; by variation of the solvent and the reaction conditions, or by quenching with 1N DCl instead of HCl; the chemical and optical yield of the product was investigated involving also the recovered chiral amine; Product distributionMechanism;
参考文献
Eleveld, M. B.; Hogeveen, H.
Tetrahedron Letters, 1986 , vol. 27, # 5 p. 631 - 634
反应条件
1: sodium bisulphate / H2O / 6 h / 0 - 15 °C 2: SOCl2, pyridine / benzene / 1 h / Heating 3: 1.8548 g / benzoyl peroxide, N-bromosuccinimide / CCl4 / 0.67 h / Heating 4: 27 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 4 h / Heating 5: 63 percent / DIBAL-H / benzene / 2.5 h / Ambient temperature View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 70, # 7 p. 2094 - 2114
反应条件
1: 90 percent / NH2NH2*H2O; Et3N / ethanol 2: 75 percent / DBN / diethyl ether 3: t-BuLi / tetrahydrofuran / -78 - 0 °C 4: TlOH / Pd(PPh3)4 / H2O / 12 h / 25 °C 5: TPAP; NMO / 4 h / 0 - 25 °C 6: 52 percent / n-BuLi; DMPU / tetrahydrofuran / -115 - -40 °C 7: 91 percent / KOH / ethanol; H2O / 70 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
反应条件
1: 90 percent / NH2NH2*H2O; Et3N / ethanol 2: 75 percent / DBN / diethyl ether 3: t-BuLi / tetrahydrofuran / -78 - 0 °C 4: TlOH / Pd(PPh3)4 / H2O / 12 h / 25 °C 5: TPAP; NMO / 4 h / 0 - 25 °C 6: 52 percent / n-BuLi; DMPU / tetrahydrofuran / -115 - -40 °C 7: 91 percent / KOH / ethanol; H2O / 70 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 47 p. 8287 - 8290
反应条件
1: Et3N / CH2Cl2 2: n-chloroperbenzoic acid (mCPBA) / CH2Cl2 3: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran 4: 75 percent 5: 80 percent / NaH / benzene / 0.5 h / Ambient temperature View Scheme
参考文献
Gronnier, Colombe; Kramer, Soren; Odabachian, Yann; Gagosz, Fabien
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 828 - 831
反应条件
1: (i) NaH, MeOH, (ii) /BRN= 1905593/ 2: aq. KOH / Heating 3: (i) aq. NaHCO3, (ii) (COCl)2, Py, Et2O 4: (i) Et2O, (ii) HCl, (iii) Zn, KI, aq. AcOH 5: pyrrolidine / benzene / Heating View Scheme
参考文献
Meyer,W.L. et al.
Journal of Organic Chemistry, 1975 , vol. 40, p. 3686 - 3694
反应条件
1: Et3N / CH2Cl2 2: n-chloroperbenzoic acid (mCPBA) / CH2Cl2 3: tetrabutylammonium fluoride (TBAF) / tetrahydrofuran 4: 75 percent 5: 80 percent / NaH / benzene / 0.5 h / Ambient temperature View Scheme
参考文献
Gronnier, Colombe; Kramer, Soren; Odabachian, Yann; Gagosz, Fabien
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 828 - 831
反应条件
1: 1.) t-BuLi / 1.) pentane, -20 deg C, 2 h, 2.) THF, -10 deg C, 2 h 2: 93 percent / molecular sieves 4A / benzene / 72 h / Ambient temperature View Scheme
参考文献
Fetizon, Marcel; Goulaouic, Pierre; Hanna, Issam; Prange, Thierry
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5672 - 5679
