2,2,6-三甲基环己酮合成路线 （共 96 条）
反应条件
1: sodium bisulphate / H2O / 6 h / 0 - 15 °C 2: SOCl2, pyridine / benzene / 1 h / Heating 3: 90 percent / DIBAL-H / benzene; toluene / 2 h / 0 °C View Scheme
参考文献
Kutney, James P.; Gunning, Philip J.; Clewley, Robin G.; Somerville, John; Rettig, Steven J.
Canadian Journal of Chemistry, 1992 , vol. 70, # 7 p. 2094 - 2114
反应条件
1: With hydrazine hydrate; triethylamine in acetonitrile T=100°C; 2: With iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene in diethyl ether T=100°C;
参考文献
Alvarez; Dominguez; De Lera
Synthetic Communications, 2001 , vol. 31, # 13 p. 2083 - 2087
反应条件
1: With bromine 2: With pyridine Heating;
参考文献
Fernandez-Mateos; Ramos Silvo; Rubio Gonzalez; Simmonds
Tetrahedron, 2006 , vol. 62, # 33 p. 7809 - 7816
反应条件
1.1: Br2 1.2: pyridine / Heating 2.1: 88 percent / tetrahydrofuran / Heating 3.1: 54 percent / P2O5; Celite / toluene / Heating 4.1: 78 percent / KOH 5.1: ethanol; H2O / 45 °C / pH 3.0 View Scheme
参考文献
Kutney, James P.; Gunning, Philip J.; Clewley, Robin G.; Somerville, John; Rettig, Steven J.
Canadian Journal of Chemistry, 1992 , vol. 70, # 7 p. 2094 - 2114
反应条件
1,4-dioxane; diethyl ether; bromine
参考文献
Jung, Michael E.; Allen, Damian A.
Organic Letters, 2008 , vol. 10, # 10 p. 2039 - 2041
反应条件
hydrogenchloride; chiral LiN(CH(CH3)Ph)2 Multistep reaction; by variation of the solvent and the reaction conditions, or by quenching with 1N DCl instead of HCl; the chemical and optical yield of the product was investigated involving also the recovered chiral amine; Product distributionMechanism;
参考文献
Eleveld, M. B.; Hogeveen, H.
Tetrahedron Letters, 1986 , vol. 27, # 5 p. 631 - 634
反应条件
2: KOH / methanol / Heating 3: aq. HCO2H View Scheme
参考文献
Ohloff, Guenther; Rautenstrauch, Valentin; Schulte-Elte, Karl H.
Helvetica Chimica Acta, 1973 , vol. 56, # 5 p. 1503 - 1513
反应条件
1: 84 percent / n-BuLi, diisopropylamine / hexane; tetrahydrofuran / 1.) dry ice-acetone temperature, 2 h, 2.) 0 deg C, overnight 2: 88 percent / Et3N, bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 18 h / 75 °C View Scheme
参考文献
Breining, Tibor; Schmidt, Cirill; Polos, Katalin
Synthetic Communications, 1987 , vol. 17, # 1 p. 85 - 88
反应条件
hydrogenchloride; chiral LiN(CH(CH3)Ph)2 Multistep reaction; by variation of the solvent and the reaction conditions, or by quenching with 1N DCl instead of HCl; the chemical and optical yield of the product was investigated involving also the recovered chiral amine; Product distributionMechanism;
参考文献
Eleveld, M. B.; Hogeveen, H.
Tetrahedron Letters, 1986 , vol. 27, # 5 p. 631 - 634
反应条件
1: 90 percent / NH2NH2*H2O; Et3N / ethanol 2: 75 percent / DBN / diethyl ether 3: t-BuLi / tetrahydrofuran / -78 - 0 °C 4: TlOH / Pd(PPh3)4 / H2O / 12 h / 25 °C 5: TPAP; NMO / 4 h / 0 - 25 °C 6: 52 percent / n-BuLi; DMPU / tetrahydrofuran / -115 - -40 °C 7: 91 percent / KOH / ethanol; H2O / 70 °C View Scheme
参考文献
Tadikonda, Praveen K.; Lacy, James M.; Rigdon, Michael G.; Deluca, Hector F.
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 1 p. 1 - 10
