2-(2-噻吩)-1,3-噻唑-4-羧酸乙酯合成路线 （共 11 条）
反应条件
2,6-dimethylpyridine; potassium hydrogencarbonate; trifluoroacetic anhydride in ethylene glycol dimethyl ether T=0 - 20°C;
参考文献
Shanghai Puyi Chemical Co., Ltd.; NAN, Fajun; CHEN, Fei; ZHANG, Yangming; LI, Jia; ZHOU, Yubo; SU, Mingbo; DING, Jian; MENG, Linghua; XIE, Xin; WANG, Shixian
Patent: EP2708534 A1, 2014 ;
Location in patent: Paragraph 0056 ;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 20 p. 3491 - 3495
反应条件
1: KOH / ethanol / 4 h / 20 °C 2: 0.25 h / 170 °C View Scheme
参考文献
Bulletin de la Societe chimique de France, , vol. 5, p. 1762 - 1768
反应条件
1: ethanol / 0.5 h / Heating 2: KOH / ethanol / 4 h / 20 °C 3: 0.25 h / 170 °C View Scheme
参考文献
Bulletin de la Societe chimique de France, , vol. 5, p. 1762 - 1768
反应条件
1: ethanol / 0.5 h / Heating 2: KOH / ethanol / 4 h / 20 °C 3: 0.25 h / 170 °C View Scheme
参考文献
Bulletin de la Societe chimique de France, , vol. 5, p. 1762 - 1768
反应条件
1: Lawesson's reagent / ethylene glycol dimethyl ether / 12 h / 20 °C / |Inert atmosphere 2: potassium hydrogencarbonate; trifluoroacetic anhydride; 2,6-dimethylpyridine / ethylene glycol dimethyl ether / 0 - 20 °C View Scheme
参考文献
Bulletin de la Societe chimique de France, , vol. 5, p. 1762 - 1768
反应条件
potassium hydroxide in methanol 0.0833333 h; Heating;
参考文献
Shanghai Puyi Chemical Co., Ltd.; NAN, Fajun; CHEN, Fei; ZHANG, Yangming; LI, Jia; ZHOU, Yubo; SU, Mingbo; DING, Jian; MENG, Linghua; XIE, Xin; WANG, Shixian
Patent: EP2708534 A1, 2014 ;
Location in patent: Paragraph 0057 ;
反应条件
hydrazine hydrate in ethanol 4 h; Heating;
参考文献
Singh, S. P.; Ranjana
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 11 p. 1130 - 1136
反应条件
1: aq. KOH / 50 °C 2: oxalyl chloride; DMF / CH2Cl2 / 20 °C View Scheme
参考文献
Larsen, Scott D.; Stachew, Carl F.; Clare, Paula M.; Cubbage, Jerry W.; Leach, Karen L.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3491 - 3495
