1: With trichlorophosphate T=20 - 70°C; 4 h; 2: With hydrogenchloride in water; N,N-dimethyl-formamide T=20 - 55°C; 2 h;

1: 74 percent / N,N-diisopropylethylamine / CH2Cl2 / 1 h / 0 - 20 °C 2: 72 percent / N,N-diisopropylethylamine / acetonitrile; methanol; hexane / 20 °C 3: 89 percent / aq. HCl / methanol / 1 h / Heating View Scheme

1: 72 percent / N,N-diisopropylethylamine / acetonitrile; methanol; hexane / 20 °C 2: 89 percent / aq. HCl / methanol / 1 h / Heating View Scheme