(6alpha,9beta,11beta,16alpha)-9,11-环氧-6-氟-17,21-二羟基-16-甲基-孕甾-1,4-二烯-3,20-二酮合成路线 (共 4 条)
反应条件
water; potassium carbonate in methanol 10 h;
参考文献
TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor
Patent: WO2012/11106 A1, 2012 ;
Location in patent: Page/Page column 19-20 ;
反应条件
methanolic potassium hydroxide
参考文献
Blasinachim S.p.A.
Patent: US4188322 A1, 1980 ;
反应条件
1: hydrogen fluoride / 5 h / -15 - -10 °C 2: trimethylsilyl iodide / acetonitrile / 2 h / -20 °C / Inert atmosphere View Scheme
反应条件
hydrogen fluoride T=-15 - -10°C; 5 h;
参考文献
TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor
Patent: WO2012/11106 A1, 2012 ;
Location in patent: Page/Page column 20 ;