5-溴-1,3-二甲氧基-2-氨基苯合成路线 （共 3 条）
反应条件
1: With bromine in dichloromethane T=0°C; 5.5 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/79836 A2, 2008 ;
Location in patent: Page/Page column 129-130 ;
WO 2008/079836 A2
反应条件
iron; ammonium chloride in methanol; water T=80°C; 4 h;
参考文献
Samanta, Subhas; Beharry, Andrew A.; Sadovski, Oleg; McCormick, Theresa M.; Babalhavaeji, Amirhossein; Tropepe, Vince; Woolley, G. Andrew
Journal of the American Chemical Society, 2013 , vol. 135, # 26 p. 9777 - 9784
反应条件
1: acetic anhydride; nitric acid / 0 - 20 °C 2: ammonium chloride; iron / water; methanol / 4 h / 80 °C View Scheme
参考文献
Samanta, Subhas; Beharry, Andrew A.; Sadovski, Oleg; McCormick, Theresa M.; Babalhavaeji, Amirhossein; Tropepe, Vince; Woolley, G. Andrew
Journal of the American Chemical Society, 2013 , vol. 135, # 26 p. 9777 - 9784
