2-([1,1-联苯]-3-基)乙酸合成路线 （共 15 条）
反应条件
1: 1.) t-BuLi / 1.) Et2O, pentane, -78 deg C, 30 min, 2.) Et2O, pentane, from -78 deg C to RT, 1 h 2: 30 percent / CrO3, aq. H2SO4 / acetone / 0.33 h / 0 °C View Scheme
参考文献
Pendergast; Johnson; Dickerson; Dev; Duch; Ferone; Hall; Humphreys; Kelly; Wilson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2279 - 2291
反应条件
1: concd HCl / methanol / 4 h / Heating 2: HCl / 2 h / Heating 3: 1.) aq. NaNO2, concd HCl, 2.) H3PO2 / 1.) DMF, 0 deg C, 2.) DMF, 0-5 deg C, 59 h View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Kunimoto, Katsutoshi; Tada, Shin-ichi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 43 - 47
反应条件
1: NBS 3: H2SO4 View Scheme
参考文献
Ruechardt,C.; Grundmeier,M.
Chemische Berichte, 1975 , vol. 108, p. 2448 - 2464
反应条件
1: 93 percent / SOCl2 / CHCl3 / 2 h / Heating
2: 62 percent / 6N NaOH / H2O / 3 h / 10 °C
View Scheme
参考文献
Tikk, I.; Toth, G.; Deak, Gy.
Acta Chimica Hungarica, 1983 , vol. 114, # 3-4 p. 355 - 360
反应条件
1: HCl / 1 h / Heating
2: 66 percent / aq. NaOH, n-Bu4N(HSO4) / CH2Cl2 / 4 h / Ambient temperature
3: 71 percent / aq. NaOH / methanol / 1 h / Heating
View Scheme
参考文献
Tamura, Yasumitsu; Yoshimoto, Yoshihiko; Kunimoto, Katsutoshi; Tada, Shin-ichi; Matsumura, Shingo; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 43 - 47
