2-([1,1-联苯]-3-基)乙酸合成路线 （共 15 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether T=100°C; 16 h; Inert atmosphere;
参考文献
Kambe, Tohru; Maruyama, Toru; Nagase, Toshihiko; Ogawa, Seiji; Minamoto, Chiaki; Sakata, Kiyoto; Maruyama, Takayuki; Nakai, Hisao; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 702 - 713
反应条件
lithium hydroxide in tetrahydrofuran T=20°C; 16 h;
参考文献
Ortar, Giorgio; Cascio, Maria Grazia; De Petrocellis, Luciano; Morera, Enrico; Rossi, Francesca; Schiano-Moriello, Aniello; Nalli, Marianna; De Novellis, Vito; Woodward, David F.; Maione, Sabatino; Di Marzo, Vincenzo
Journal of Medicinal Chemistry, 2007 , vol. 50, # 26 p. 6554 - 6569
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=760 Torr; 12 h;
参考文献
Kotoris, Christopher C.; Chen, Mei-Jin; Taylor, Scott D.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3275 - 3280
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 16 h; 2: With hydrogenchloride in water pH=3;
参考文献
MERCK and CO., INC.
Patent: WO2007/89634 A2, 2007 ;
Location in patent: Page/Page column 33-34 ;
WO 2007/089634 A2
反应条件
chromium(VI) oxide; sulfuric acid in acetone T=0°C; 0.333333 h;
参考文献
Pendergast; Johnson; Dickerson; Dev; Duch; Ferone; Hall; Humphreys; Kelly; Wilson
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2279 - 2291
反应条件
morpholine; sulfur Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH;
参考文献
Sam; Shafik
Journal of pharmaceutical sciences, 1969 , vol. 58, # 8 p. 952 - 955
参考文献
Kotsikorou, Evangelia; Song, Yongcheng; Chan, Julian M. W.; Faelens, Stephanie; Tovian, Zev; Broderick, Erin; Bakalara, Norbert; Docampo, Roberta; Oldfield, Eric
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 6128 - 6139
反应条件
1: dimethylsulfoxide / 6 h / 20 °C 2: aq. NaOH / ethanol / 1 h / Heating View Scheme
参考文献
Ruechardt,C.; Grundmeier,M.
Chemische Berichte, 1975 , vol. 108, p. 2448 - 2464
反应条件
1: 89 percent / Cs2CO3 / methanol; H2O 2: 70 percent / Na2CO3, Pd(OAc)2 / 24 h / Ambient temperature 3: 85 percent / H2 / 5percent Pd/C / ethyl acetate / 12 h / 760 Torr View Scheme
参考文献
Kotoris, Christopher C.; Chen, Mei-Jin; Taylor, Scott D.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3275 - 3280
反应条件
1: 70 percent / Na2CO3, Pd(OAc)2 / 24 h / Ambient temperature 2: 85 percent / H2 / 5percent Pd/C / ethyl acetate / 12 h / 760 Torr View Scheme
参考文献
Kotoris, Christopher C.; Chen, Mei-Jin; Taylor, Scott D.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3275 - 3280
