Nε-Boc-Nα-Cbz-L-赖氨酸合成路线 （共 24 条）
反应条件
in isopropanol acetate
参考文献
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A
Patent: WO2008/14811 A1, 2008 ;
Location in patent: Page/Page column 17-18 ;
反应条件
dicyclohexyl-carbodiimide
参考文献
Schnabel,E.
Justus Liebigs Annalen der Chemie, 1964 , vol. 674, p. 218 - 225
反应条件
trifluoroacetic acid T=10 - 15°C;
参考文献
Mitsubishi Pharma Corporation
Patent: EP1426366 A1, 2004 ;
Location in patent: Page 28-29 ;
反应条件
1: 56 percent / ClCO2Et; Et3N; NH3 / tetrahydrofuran / 10 - 20 °C
2: 87 percent / (CF3CO)2; Et3N / tetrahydrofuran / 0 °C
3: 72 percent / Raney-Ni; H2; NH3 / methanol / 72 h / 50 °C / 5168.35 Torr
View Scheme
参考文献
Zhou; Shearer; Rokita
Journal of the American Chemical Society, 2000 , vol. 122, # 37 p. 9046 - 9047
