Nε-Boc-Nα-Cbz-L-赖氨酸合成路线 （共 24 条）
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=20°C;
参考文献
WO2007/127173 A2, ;
Page/Page column 34 ;
反应条件
1: anhydrous L-lysine monohydrochloride; N-Boc-1H-benzotriazole With sodium hydroxide in tetrahydrofuran; water T=0°C; pH=11.5; 2: benzyl chloroformate in tetrahydrofuran; water pH=10 - 11; 3: With hydrogenchloride in isopropanol acetate; water pH=2;
参考文献
WO2008/14811 A1, ;
Page/Page column 17-18 ;
参考文献
Journal of the American Chemical Society, , vol. 104, # 16 p. 4446 - 4450
参考文献
Journal of the American Chemical Society, , vol. 87, p. 99 - 104
反应条件
TMG in dimethyl sulfoxide T=50°C; 4.5 h;
参考文献
Synthetic Communications, , vol. 11, # 4 p. 303 - 314
反应条件
1.1: 2M aq. NaHCO3; CuSO4*5H2O 1.2: NaHCO3 / H2O; acetone / 24 h 1.3: 8-quinolinol / H2O / 5 h 2.1: Na2CO3 / H2O; acetone / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 10 p. 1489 - 1490
反应条件
1: 1.) NaOH, 2.) aq. HCl / 1) -20 - -5.5 deg C, H2O, EtOH; 2) 50 deg C 2: 866 g / tetramethylguanidine / dimethylsulfoxide / 4.5 h / 50 °C View Scheme
参考文献
Synthetic Communications, , vol. 11, # 4 p. 303 - 314
反应条件
1.1: 2M aq. NaHCO3; CuSO4*5H2O 1.2: NaHCO3 / H2O; acetone / 24 h 1.3: 8-quinolinol / H2O / 5 h 2.1: Na2CO3 / H2O; acetone / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 10 p. 1489 - 1490
反应条件
1: Na2CO3 / H2O; acetone / 0.5 h 2: Na2CO3 / H2O; acetone / 1 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 10 p. 1489 - 1490
反应条件
sodium carbonate in water; acetone Acylation; 1 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 47, # 10 p. 1489 - 1490
