4-甲基-5,6-二氢吡喃-2-酮合成路线 （共 28 条）
反应条件
1: 91 percent / Me2S / tetrahydrofuran; diethyl ether / 0.5 h / -25 - -17 °C
2: mCPBA / CH2Cl2 / -15 °C
3: 72 percent / pyridine / benzene / Heating
View Scheme
参考文献
Kato, Michiharu; Ouchi, Akihiko; Yoshikoshi, Akira
Chemistry Letters, 1983 , p. 1511 - 1514
反应条件
1: mCPBA / CH2Cl2 / -15 °C
2: 72 percent / pyridine / benzene / Heating
View Scheme
参考文献
Kato, Michiharu; Ouchi, Akihiko; Yoshikoshi, Akira
Chemistry Letters, 1983 , p. 1511 - 1514
反应条件
in benzene
10 h; Heating;
参考文献
Kumar, Pradeep; Saravanan
Tetrahedron, 1998 , vol. 54, # 10 p. 2161 - 2168
反应条件
1: SOCl2; Et3N / CH2Cl2 / 0.33 h / 0 °C
2: NaIO4; RuCl3*H2O / dimethylsulfoxide; acetonitrile; H2O / 2 h / 0 °C
3: dimethylformamide / 8 h / 80 °C
4: aq. H2SO4 / ethanol / 18 h / Heating
View Scheme
参考文献
Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Asymmetry, 1999 , vol. 10, # 22 p. 4349 - 4356
反应条件
1: dimethylformamide / 8 h / 80 °C
2: aq. H2SO4 / ethanol / 18 h / Heating
View Scheme
参考文献
Fernandes, Rodney A.; Kumar, Pradeep
Tetrahedron Asymmetry, 1999 , vol. 10, # 22 p. 4349 - 4356
反应条件
1: 1) diisopropylamine, butyllithium / 1) THF, hexane, 78 deg C, 10 min, 2) THF, HMPA, to r.t. in 10 h
2: 1.617 g / mCPBA / CH2Cl2 / 0.5 h
3: 98 percent / trifluoroacetic anhydride / CH2Cl2 / 12 h
4: 1) Cu(I)I / 1) -35 deg C, 50 min, ether, 2) -35 to -18 deg C, THF, 30 min
5: mCPBA / CH2Cl2 / 0.17 h / -10 °C
6: pyridine / benzene / 1.5 h / Heating
View Scheme
参考文献
Kato, Michiharu; Ouchi, Akihiko; Yoshikoshi, Akira
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 5 p. 1479 - 1486
反应条件
1: 95 percent / LAH / tetrahydrofuran / 24 h / Ambient temperature
2: 31 percent / Jones reagent / acetone / 0 °C
View Scheme
参考文献
Nangia; Rao; Prasuna
Synthetic Communications, 1992 , vol. 22, # 4 p. 593 - 602
反应条件
1: Ac2O / 0.5 h / 70 °C
2: 95 percent / LAH / tetrahydrofuran / 24 h / Ambient temperature
3: 31 percent / Jones reagent / acetone / 0 °C
View Scheme
参考文献
Nangia; Rao; Prasuna
Synthetic Communications, 1992 , vol. 22, # 4 p. 593 - 602
反应条件
1: 98 percent / trifluoroacetic anhydride / CH2Cl2 / 12 h
2: 1) Cu(I)I / 1) -35 deg C, 50 min, ether, 2) -35 to -18 deg C, THF, 30 min
3: mCPBA / CH2Cl2 / 0.17 h / -10 °C
4: pyridine / benzene / 1.5 h / Heating
View Scheme
参考文献
Kato, Michiharu; Ouchi, Akihiko; Yoshikoshi, Akira
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 5 p. 1479 - 1486
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride in acetonitrile
1 h; Ambient temperature;
参考文献
Nangia, A.; Rao, P. Bheema
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2375 - 2378
