反应条件
1: 1.) hydrobromic acid, sodium nitrite, 2.) coopper(I) bromide / 1.) water, 1,4-dioxane, 0 deg C, 15 min, 2.) a) 0 deg C, 15 min, b) 60 deg C, 15 min 2: 44 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 10 h / Ambient temperature 3: 93 percent / iron / ethanol; acetic acid / 3.5 h / Heating 4: 60 percent / pyridine / 6 h / Ambient temperature 5: 36 percent / tetrakis(triphenylphosphine)palladium(0) / toluene / Heating 6: 58 percent / bis(acetonitrile)palladium chloride, p-benzoquinone, lithium chloride / dimethylformamide / 28 h / 100 - 110 °C 7: 83 percent / 20percent aq. NaOH / methanol / 12 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 6 p. 1170 - 1176
