5-甲氧基-1H-吲哚-6-醇合成路线 （共 9 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
P=775.7 Torr; 2 h;
参考文献
Rogers, C. Bradford; Blum, Charles A.; Murphy, Bryan P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 941 - 943
反应条件
formic acid; ammonium formate; palladium on activated charcoal in methanol
T=20°C; 9 h;
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1: 78 percent / HNO3; H2SO4; AcOH / 1 h / 20 °C
2: 59 percent / NH4OAc / 2 h / Heating
3: 31 percent / HCOONH4; formic acid / Pd/C / methanol / 9 h / 20 °C
View Scheme
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1: 59 percent / NH4OAc / 2 h / Heating
2: 31 percent / HCOONH4; formic acid / Pd/C / methanol / 9 h / 20 °C
View Scheme
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1: 95 percent / K2CO3 / acetone / 4 h / Heating
2: 78 percent / HNO3; H2SO4; AcOH / 1 h / 20 °C
3: 59 percent / NH4OAc / 2 h / Heating
4: 31 percent / HCOONH4; formic acid / Pd/C / methanol / 9 h / 20 °C
View Scheme
参考文献
Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373
反应条件
1: 85 percent / ammonium acetate / acetic acid / 1.5 h
2: 35 percent / H2 / 10percent Pd/C / methanol / 2 h / 775.7 Torr
View Scheme
参考文献
Rogers, C. Bradford; Blum, Charles A.; Murphy, Bryan P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 941 - 943
反应条件
1: KF, 18-crown-8 / propan-2-ol / 5 h
2: acetic anhydride, sodium acetate / overnight
3: 92 percent / K2CO3 / ethanol / Ambient temperature
4: 35 percent / H2 / 10percent Pd/C / methanol / 2 h / 775.7 Torr
View Scheme
参考文献
Rogers, C. Bradford; Blum, Charles A.; Murphy, Bryan P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 941 - 943
反应条件
1: 92 percent / K2CO3 / ethanol / Ambient temperature
2: 35 percent / H2 / 10percent Pd/C / methanol / 2 h / 775.7 Torr
View Scheme
参考文献
Rogers, C. Bradford; Blum, Charles A.; Murphy, Bryan P.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 941 - 943
反应条件
methanol; sodium hydroxide; water
T=0°C; Regans 4: Natriumdithionit;
参考文献
Beer et al.
Journal of the Chemical Society, 1948 , p. 2223,2224
