4-羟基-3-甲氧基苯乙醇合成路线 （共 16 条）
反应条件
in methanol 0.5 h; Heating; Title compound not separated from byproducts;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 32, # 8 p. 3009 - 3014
反应条件
(i) nBuLi, Et2O, (ii) /BRN= 102378/, Et2O, benzene; Multistep reaction;
参考文献
Monatshefte fuer Chemie, , vol. 97, p. 744 - 753
反应条件
sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine in dichloromethane; dimethyl sulfoxide T=-15°C; Parikh-Doering Oxidation; 0.5 h; Inert atmosphere;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 16 p. 2997 - 3008
反应条件
1: With AlCl3, aluminium chloride in ethanethiol T=0 - 20°C; 42 h; 2: With hydrogenchloride; water Cooling with ice;
参考文献
LONZA LTD; YANG, Zhengyi; TAN, Fengyu; WONG, Heilam; HANSELMANN, Paul
Patent: WO2012/3625 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
sodium hydroxide in ethanol; water
6 h; Heating / reflux;
参考文献
CARDIOME PHARMA CORP.; ROTH, Carol, J.
Patent: WO2005/97087 A2, 2005 ;
Location in patent: Page/Page column 68 ;
参考文献
Walpole; Wrigglesworth; Bevan; Campbell; Dray; James; Masdin; Perkins; Winter
Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2373 - 2380
