3,3-二甲基-2-哌啶酮合成路线 （共 3 条）
反应条件
1: 3,3-dimethyl-1-(trimethylsilyl)-piperidin-2-one; methyl iodide With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78 - -20°C; 0.25 h; 2: methyl iodide With lithium diisopropyl amide in tetrahydrofuran; hexane T=25°C; 0.5 h; Further stages.;
参考文献
Ahn; Cardenas; Yang; Romo
Organic letters, 2001 , vol. 3, # 5 p. 751 - 754
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.25 h;
参考文献
Padwa; Harring; Hertzog; Nadler
Synthesis, 1994 , # 9 p. 993 - 1004
反应条件
hydroxylamine-o-sulphonic acid T=15 - 100°C;
参考文献
F. HOFFMANN-LA ROCHE AG; JAESCHKE, Georg; JOLIDON, Synese; LINDEMANN, Lothar; STADLER, Heinz; VIEIRA, Eric
Patent: WO2012/146551 A1, 2012 ;
Location in patent: Page/Page column 32-33 ;
