2-苯基-4-羟甲基噻唑合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=-78°C; 3.83 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00145 ;
反应条件
sodium hydroxide; water in tetrahydrofuran; methanol T=20°C; 0.0833333 h;
参考文献
EP1228067 B1, ;
Page 67 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78°C; 2 h;
参考文献
Kwon, Il-Chun; Koh, Young Kook; Choi, Jun-Hyeak; Kim, Hong-Seok
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1883 - 1886
反应条件
2: aqueous NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 65, p. 1667,1669
参考文献
Journal of the American Chemical Society, , vol. 65, p. 1667,1669
反应条件
methanesulfonic acid; carbonic acid dimethyl ester T=120°C; 1.33333 h; Microwave irradiation;
参考文献
Orr, David; Tolfrey, Alexandra; Percy, Jonathan M.; Frieman, Joanna; Harrison, Zoe A.; Campbell-Crawford, Matthew; Patel, Vipulkumar K.
Chemistry - A European Journal, 2013 , vol. 19, # 29 p. 9655 - 9662
反应条件
1: pyridine; hydrogen sulfide; triethylamine 2: toluene / 2 h / Reflux 3: sulfuric acid; water / Reflux View Scheme
参考文献
Archiv der Pharmazie, , vol. 343, # 7 p. 411 - 416
反应条件
1: CrO3; H2SO4 2: SOCl2 View Scheme
参考文献
Huntress; Pfister
Journal of the American Chemical Society, 1943 , vol. 65, p. 1667,1669
反应条件
chromium(VI) oxide; sulfuric acid
参考文献
Simiti; Farkas
Archiv der Pharmazie, 1974 , vol. 307, # 2 p. 81 - 88
反应条件
oxalyl dichloride; dimethyl sulfoxide; triethylamine in dichloromethane T=-78 - 0°C; Swern oxidation;
参考文献
Millan, David S.; Prager, Rolf H.; Brand, Catherine; Hart, Prue H.
Tetrahedron, 2000 , vol. 56, # 5 p. 811 - 816
