1: With n-butyllithium in tetrahydrofuran; hexane T=-50°C; 1 h; 2: With sodium hydroxide in tetrahydrofuran; hexane; water

n-butyllithium T=-75°C; 3 h;

1: in tetrahydrofuran T=-60°C; 0.5 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=3.4;

1.1: phosgene / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C 1.2: 0.5 h / 20 °C 2.1: lithium borohydride / tetrahydrofuran / 20 °C 3.1: Dess-Martin periodane / dichloromethane / 20 °C View Scheme