2-氯-4-氨基-6,7-二甲氧基喹唑啉合成路线 （共 26 条）
反应条件
trichlorophosphate T=25 - 70°C; 1 h;
参考文献
UNICHEM LABORATORIES LIMITED
Patent: WO2008/84493 A2, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
ammonia in tetrahydrofuran T=20°C; 44 h;
参考文献
Andrus, Merritt B; Mettath, Sashikumar N; Song, Chun
The Journal of organic chemistry, 2002 , vol. 67, # 23 p. 8284 - 8286
反应条件
ammonia in tetrahydrofuran
反应条件
2-iodo-pyridine; triphenylphosphine; zinc; palladium diacetate in N,N-dimethyl-formamide T=50°C;
参考文献
Tetrahedron Letters, , vol. 46, # 6 p. 983 - 986
反应条件
1: 213 g / nitric acid / 1.17 h / cooling 2: hydrogen / Pd/C 3: acid 4: 87 g / phosphorus oxychloride / dimethylformamide / 8 h / Heating 5: ammonia / H2O; tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 36, # 4 p. 341 - 345
反应条件
1: hydrogen / Pd/C 2: acid 3: 87 g / phosphorus oxychloride / dimethylformamide / 8 h / Heating 4: ammonia / H2O; tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 36, # 4 p. 341 - 345
反应条件
triphenylphosphine; palladium diacetate in tetrahydrofuran Negishi coupling; Heating;
参考文献
Tetrahedron Letters, , vol. 46, # 6 p. 983 - 986
反应条件
1: 68 percent / POCl3; N,N-dimethylaniline / 4.5 h / Heating 2: 68 percent / NH3 / tetrahydrofuran / 44 h / 20 °C View Scheme
参考文献
The Journal of organic chemistry, , vol. 67, # 23 p. 8284 - 8286
反应条件
1: acid 2: 87 g / phosphorus oxychloride / dimethylformamide / 8 h / Heating 3: ammonia / H2O; tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 36, # 4 p. 341 - 345
反应条件
1: thionyl chloride; ammonia; N-butylamine 2: iron; ammonium chloride 3: hydrogenchloride / water 4: ammonia View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 13 p. 3959 - 3966
