N-Boc-O-苄基-L-丝氨酸合成路线 (共 43 条)
反应条件
hydrogenchloride; thionyl chloride in ethanol
参考文献
FUJIREBIO Inc.
Patent: EP520336 A2, 1992 ;
EP 0520336 A2
反应条件
1: C16H22NO4PolS With 3-methyl-phenol; trifluoroacetic acid
0.25 h; Automated synthesizersolid phase reaction;
2: N-tert-butoxycarbonyl-O-benzyl-L-serine With 1-methyl-pyrrolidin-2-one; benzotriazol-1-ol; diisopropyl-carbodiimide
1 h; Automated synthesizersolid phase reaction;
3: BOC-glycine; N-tert-butoxycarbonyl-L-alanine; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-L-threonine benzyl ether; BOC-S-4-methoxybenzyl-L-cysteine; N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-L-lysine; N-BOC-D-tryptophan; Boc-Asn(Xan)-OH Further stages;
参考文献
Erchegyi, Judit; Cescato, Renzo; Waser, Beatrice; Rivier, Jean E.; Reubi, Jean Claude
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 5981 - 5987
反应条件
Yield given. Multistep reaction;
参考文献
Stetler-Stevenson, Mary Alice; Yang, Dai Chang; Lipkowski, Andrew; McCartney, Linda; Peterson, Darryl; Fluoret, George
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 688 - 692