N-Boc-O-苄基-L-丝氨酸合成路线 （共 43 条）
反应条件
Yield given. Multistep reaction;
参考文献
Stetler-Stevenson, Mary Alice; Yang, Dai Chang; Lipkowski, Andrew; McCartney, Linda; Peterson, Darryl; Fluoret, George
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 688 - 692
反应条件
1: 96 percent / BF3*Et2O / CH2Cl2; cyclohexane / 20 h / 20 °C 2: 99 percent / H2; acetic acid / Pd(OH)2/C / ethanol / 36 h / 20 °C View Scheme
参考文献
Inami; Teshima; Emura; Shiba
Tetrahedron Letters, 1990 , vol. 31, # 28 p. 4033 - 4036
反应条件
dimethylsulfide; hydrogen fluoride T=0°C; 2 h; Var.: HF in anisole; Product distribution;
参考文献
Tetrahedron Letters, , vol. 23, # 43 p. 4435 - 4438
反应条件
1.1: trifluoroacetic acid / 0.75 h / 20 °C 1.2: 20 h / 5 - 20 °C / pH 4 2.1: sulfuric acid / 16 h / Reflux View Scheme
反应条件
1: N-tert-butoxycarbonyl-O-benzyl-L-serine With trifluoroacetic acid T=20°C; 1 h; 2: With water; sodium nitrite in acetone T=5 - 20°C; pH=4; 16 h; 3: trimethyl orthoformate With sulfuric acid in methanol 16 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 353 - 359
反应条件
1: With trifluoroacetic acid T=20°C; 0.75 h; 2: With water; sodium acetate; sodium nitrite in acetone T=5 - 20°C; pH=4; 20 h;
参考文献
Watson, Timothy J.; Ayers, Timothy A.; Shah, Nik; Wenstrup, David; Webster, Mark; Freund, David; Horgan, Stephen; Carey, James P.
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 521 - 532
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 14 h;
参考文献
Ikeuchi, Yoshitaka; Khan, Fareha Zafar; Naoya, Onishi; Masashi, Shiotsuki; Toshio, Masuda; Yoshiyuki, Nishio; Fumio, Sanda
Journal of Polymer Science, Part A: Polymer Chemistry, 2010 , vol. 48, # 18 p. 3986 - 3993
反应条件
pyridine in acetonitrile T=20°C; 1.5 h; further solvent, base;
参考文献
Il'ina, A. V.; Davidovich, Yu. A.; Rogozhin, S. V.; Moiseenkov, A. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1984 , vol. 33, p. 1067 - 1070
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1984 , # 5 p. 1163 - 1165
反应条件
4-methyl-morpholine in tetrahydrofuran; acetonitrile Ambient temperature;
参考文献
Jaoudai, Mahmoud; Martinez, Jean; Castro, Bertrand
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2364 - 2367
反应条件
1: 97 percent / BH3*THF / tetrahydrofuran / 1.) 0 deg C, 1 h; 2.) RT; 3.) 0 deg C, 1 h 2: 99 percent / triethylamine / CH2Cl2 / -3 °C 3: NaH / tetrahydrofuran / Heating 4: 100 percent / Raney Ni / ethanol; H2O / Heating View Scheme
参考文献
Donner
Tetrahedron Letters, 1995 , vol. 36, # 8 p. 1223 - 1226
