4-(N-吗啉)-苯羧酸甲酯合成路线 （共 8 条）
反应条件
caesium carbonate; P(i-BuNCH2)3CMe; palladium diacetate in toluene T=80°C; Buchwald-Hartwig amination reaction;
参考文献
Iowa State University Research Foundation, Inc.
Patent: US7385058 B1, 2008 ;
Location in patent: Page/Page column 25-26; 34-35 ;
反应条件
caesium carbonate; P(i-BuNCH2)3CMe; palladium diacetate in toluene T=110°C; Buchwald-Hartwig amination reaction; 24 h;
参考文献
Iowa State University Research Foundation, Inc.
Patent: US7385058 B1, 2008 ;
Location in patent: Page/Page column 27-30; 35 ;
反应条件
potassium phosphate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=105°C; 16 h;
参考文献
Anderson, Kevin W.; Mendez-Perez, Maria; Priego, Julian; Buchwald, Stephen L.
Journal of Organic Chemistry, 2003 , vol. 68, # 25 p. 9563 - 9573
反应条件
1: methanol With thionyl chloride Cooling with ice; 2: 4-(4-morpholinyl)-benzoic acid 1.5 h; Reflux;
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1623 - 1642
反应条件
1: 2,4,6-tris(4-carbomethoxyphenyl)boroxine With potassium carbonate in 1,4-dioxane T=130°C; 24 h; Inert atmosphere; 2: morpholino benzoate in 1,4-dioxane Inert atmosphere;
参考文献
Xiao, Qing; Tian, Leiming; Tan, Renchang; Xia, Ying; Qiu, Di; Zhang, Yan; Wang, Jianbo
Organic Letters, 2012 , vol. 14, # 16 p. 4230 - 4233
反应条件
1: 83 percent / NaH / diethyl ether / 12 h / 20 °C 2: 94 percent / K3PO4; XantPhos / Pd2dba3 / toluene / 16 h / 105 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 68, # 25 p. 9563 - 9573
反应条件
potassium hydroxide in toluene T=150°C; 1 h; microwave irradiation;
参考文献
Van Baelen, Gitte; Maes, Bert U.W.
Tetrahedron, 2008 , vol. 64, # 23 p. 5604 - 5619
反应条件
1.1: potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 2 h / 20 °C
2.1: AlCl3, aluminium chloride; dimethylsulfide / dichloromethane / 8 h / 20 °C
2.2: ice
View Scheme
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1623 - 1642
