N-(2,2,2-三氟乙酰基)-L-苯基丙氨酸甲酯合成路线 （共 14 条）
反应条件
1.1: trifluorormethanesulfonic acid / 0 °C 1.2: 10 h / 20 °C 2.1: sodium hydroxide / methanol; water; acetonitrile / 20 °C View Scheme
参考文献
Murai, Yuta; Wang, Lei; Muto, Yasuyuki; Sakihama, Yasuko; Hashidoko, Yasuyuki; Hatanaka, Yasumaru; Hashimoto, Makoto
Heterocycles, 2013 , vol. 87, # 10 p. 2119 - 2126
反应条件
in dichloromethane
T=20°C;
参考文献
Smallridge, Andrew J.; Trewhella, Maurie A.; Wang
Australian Journal of Chemistry, 2002 , vol. 55, # 4 p. 259 - 262
反应条件
subtilisin Carlsberg protease in various solvent(s)
72 h;
参考文献
Saul, Simon; Corr, Stuart; Micklefield, Jason
Angewandte Chemie - International Edition, 2004 , vol. 43, # 41 p. 5519 - 5523
反应条件
triethylamine in methanol
T=20°C;
参考文献
Maity, Sibaprasad; Kumar, Ravi; Maity, Suman Kumar; Jana, Poulami; Bera, Santu; Haldar, Debasish
MedChemComm, 2013 , vol. 4, # 3 p. 530 - 536
反应条件
modified subtilisin Carlsberg Type VIII in carbon dioxide; water
T=47°C; P=85329.4 Torr;
参考文献
Smallridge, Andrew J.; Trewhella, Maurie A.; Wang
Australian Journal of Chemistry, 2002 , vol. 55, # 4 p. 259 - 262
反应条件
modified subtilisin Carlsberg Type VIII in carbon dioxide; water
T=47°C; P=85329.4 Torr;
参考文献
Smallridge, Andrew J.; Trewhella, Maurie A.; Wang
Australian Journal of Chemistry, 2002 , vol. 55, # 4 p. 259 - 262
反应条件
1: 90 percent / p-TsOH / toluene / 100 °C
2: NaHCO3 / methanol; H2O / Heating
3: H2 / Pd/C / methanol / 12 h / 20 °C
4: HCl / 12 h / 20 °C
5: CF3CO2H / 2 h / 20 °C
View Scheme
参考文献
Allevi, Pietro; Anastasia, Mario
Tetrahedron Letters, 2003 , vol. 44, # 41 p. 7663 - 7665
反应条件
1: NaHCO3 / methanol; H2O / Heating
2: H2 / Pd/C / methanol / 12 h / 20 °C
3: HCl / 12 h / 20 °C
4: CF3CO2H / 2 h / 20 °C
View Scheme
参考文献
Allevi, Pietro; Anastasia, Mario
Tetrahedron Letters, 2003 , vol. 44, # 41 p. 7663 - 7665
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
24 h;
参考文献
Spisni, Alberto; Corradini, Roberto; Marchelli, Rosangela; Dossena, Arnaldo
Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 684 - 688
反应条件
1.1: 84 percent / KOMe / methanol / 40 °C
2.1: Vilsmeier reagent / ethyl acetate / 1 h / -5 °C
2.2: 0.44 g / ethyl acetate
View Scheme
参考文献
Jass, Paul A.; Rosso, Victor W.; Racha, Saibaba; Soundararajan, Nachimuthu; Venit, John J.; Rusowicz, Andrew; Swaminathan, Shankar; Livshitz, Julia; Delaney, Edward J.
Tetrahedron, 2003 , vol. 59, # 45 p. 9019 - 9029
