(S)-(+)-3(苄氧羰基)-5-氧代-4-恶唑啉乙酸合成路线 （共 11 条）
反应条件
toluene-4-sulfonic acid in benzene 1 h; Heating;
参考文献
Scholtz, John M.; Bartlett, Paul A.
Synthesis, 1989 , # 7 p. 542 - 544
反应条件
1: in benzene 3 h; Heating / reflux; 2: With sodium hydrogencarbonate in water; benzene 3: With hydrogenchloride in water; benzene
参考文献
PELLICCIARI, Roberto; SCHWARCZ, Robert; GUIDETTI, Paolo
Patent: WO2006/13085 A1, 2006 ;
Location in patent: Page/Page column 4-5 ;
WO 2006/013085 A1
反应条件
toluene-4-sulfonic acid in toluene 1.66667 h; Heating;
参考文献
Baldwin, Jack E.; Lee, E.
Tetrahedron, 1986 , vol. 42, # 23 p. 6551 - 6554
反应条件
boron trifluoride diethyl etherate in toluene 2 h; Heating;
参考文献
Hsiao, Chi-Nung; Leanna, M. Robert; Bhagavatula, Lakshmi; Lara, Edvin De; Zydowsky, Thomas M.; et al.
Synthetic Communications, 1990 , vol. 20, # 22 p. 3507 - 3517
反应条件
1: diphenyl diphosphorazidate, Et3N / benzene / 15 h 2: benzene / 3 h / Heating 3: 95 percent / NaOH / acetone; H2O / 2 h / 0 - 5 °C 4: 92 percent / 4 M HCl in dioxane / dioxane / 3 h View Scheme
参考文献
Noguchi, Noriyoshi; Kuroda, Tsuyoshi; Hatanaka, Minoru; Ishimaru, Toshiyasu
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 2 p. 633 - 634
反应条件
1: 82 percent / benzyltriethylammonium chloride, K2CO3 / N,N-dimethyl-acetamide / 24 h / 55 °C 2: 80 percent / 1 N NaOH / ethanol View Scheme
参考文献
Chevallet, Pierre; Garrouste, Patrick; Malawska, Barbara; Martinez, Jean
Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7409 - 7412
反应条件
in methanol T=-10 - 20°C; 5.5 h;
参考文献
Chandan, Nandkishkor; Moloney, Mark G.
Tetrahedron Letters, 2013 , vol. 54, # 15 p. 1987 - 1990
反应条件
1: 4-methyl-morpholine / tetrahydrofuran / -15 °C / Inert atmosphere 2: sodium tetrahydroborate / tetrahydrofuran 3: citric acid / 2 h / Reflux View Scheme
参考文献
Singh, Suneel P.; Michaelides, Alex; Merrill, A. Rod; Schwan, Adrian L.
Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6825 - 6831
反应条件
1: diphenyl phosphoroazidate, Et3N / 2-methyl-propan-2-ol / 2 h / 35 °C 2: 35 °C 3: NaOMe / methanol / 1 h / -10 °C View Scheme
参考文献
Scholtz, John M.; Bartlett, Paul A.
Synthesis, 1989 , # 7 p. 542 - 544
反应条件
1: 1.) diphenylphosphoryl azide, Et3N; 2.) SnCl4 / 1.) 80 deg C, 2 h, toluene; 2.) 70 deg C, 0.5 h 2: 88 percent / 1N NaOH / H2O; acetone / 3 h / 0 °C View Scheme
参考文献
Synthesis, , # 11 p. 1351 - 1352
