反式-2-苯基-1-环已醇合成路线 （共 72 条）
反应条件
(S,S)(4-JandaJel-CH2-O(CH2)3O)-2(BnN(Me)CH2)N(Me)pyrrolidine; 4 A molecular sieve; triethylamine in dichloromethane T=-78°C; 11 h;
参考文献
Clapham; Cho; Janda
Journal of Organic Chemistry, 2001 , vol. 66, # 3 p. 868 - 873
反应条件
(S)-HBTM; N-ethyl-N,N-diisopropylamine in 1,1-dimethylpropan-1-ol; toluene T=-40°C; 10 h; optical yield given as percent ee;
参考文献
Zhang, Yuhua; Birman, Vladimir B.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 14-15 p. 2525 - 2529
反应条件
via enzymatic Pseudomonas sp. acyl transfer;
参考文献
Banik, Bimal K.; Adler, Dorothy; Nguyen, Phuong; Srivastava, Neeta
Heterocycles, 2003 , vol. 61, p. 101 - 104
反应条件
(S)-HBTM; N-ethyl-N,N-diisopropylamine in chloroform-d1 T=20°C; 3 h; optical yield given as percent ee;
参考文献
Harada, Shingo; Kuwano, Satoru; Yamaoka, Yousuke; Yamada, Ken-Ichi; Takasu, Kiyosei
Angewandte Chemie - International Edition, 2013 , vol. 52, # 39 p. 10227 - 10230
Angew. Chem., 2013 , vol. 125, # 39 p. 10417 - 10420,4
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 24 h;
参考文献
Matsugi, Masato; Hagimoto, Yuri; Nojima, Masatomo; Kita, Yasuyuki
Organic Process Research and Development, 2003 , vol. 7, # 4 p. 583 - 584
反应条件
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ding, Jie; Welton, Thomas; Armstrong, Daniel W.
Analytical Chemistry, 2004 , vol. 76, # 22 p. 6819 - 6822
反应条件
N-chloro-succinimide; (S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl in tetrahydrofuran T=-74 - 20°C; Product distribution;
参考文献
Sekar; Nishiyama
Journal of the American Chemical Society, 2001 , vol. 123, # 15 p. 3603 - 3604
反应条件
1: (+/-)-trans-2-phenyl-1-cyclohexanol With (S)-(2-((dimethylamino)diphenylmethyl)pyrrolidin-1-yl)(4-(pyrrolidin-1-yl)pyridin-3-yl)methanone in dichloromethane T=-30°C; 0.5 h; Inert atmosphere; 2: acetic anhydride in dichloromethane T=-30°C; Inert atmosphere;
参考文献
Gleeson, Oliver; Gun'Ko, Yurii K.; Connon, Stephen J.
Synlett, 2013 , vol. 24, # 13 art. no. ST-2013-B0413-L, p. 1728 - 1734
反应条件
1: (+/-)-trans-2-phenyl-1-cyclohexanol With (S)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(diphenyl(1-(4-(pyrrolidin-1-yl)nicotinoyl)pyrrolidin-2-yl)methyl)urea in dichloromethane T=-30°C; 0.5 h; Inert atmosphere; 2: benzoic acid anhydride in dichloromethane T=-30°C; Inert atmosphere;
参考文献
Gleeson, Oliver; Gun'Ko, Yurii K.; Connon, Stephen J.
Synlett, 2013 , vol. 24, # 13 art. no. ST-2013-B0413-L, p. 1728 - 1734
反应条件
in various solvent(s) 96 h; Ambient temperaturePseudomonas sp. lipase;
参考文献
Journal of the Chemical Society, Chemical Communications, , # l p. 49 - 51
