N-乙酰-L-苯丙氨酸乙酯合成路线 （共 48 条）
反应条件
Tris-HCl buffer; α-chymotropsin in water; N,N-dimethyl-formamide T=25°C; pH 9;
参考文献
Aso
Agricultural and Biological Chemistry, 1989 , vol. 53, # 3 p. 729 - 733
反应条件
bovine pancreas α-chymotrypsin; water; triethylamine T=20°C;
参考文献
Maugeri, Zaira; Leitner, Walter; Dominguez De Maria, Pablo
European Journal of Organic Chemistry, 2013 , # 20 p. 4223 - 4228
反应条件
subtilisin A; water T=40°C; Ionic liquidEnzymatic reaction;
参考文献
Falcioni, Francesco; Housden, Hazel R.; Ling, Zhenlian; Shimizu, Seishi; Walker, Adam J.; Bruce, Neil C.
Chemical Communications, 2010 , vol. 46, # 5 p. 749 - 751
反应条件
water; α-chymotrypsin in water T=10 - 35°C; α-chymotrypsin-catalyzed hydrolysis in CCl4, CH2Cl2, toluene, and aqueous phosphate buffer; Thermodynamic dataEquilibrium constant;
参考文献
Tewari, Y. B.; Schantz, M. M.; Pandey, P. C.; Rekharsky, M. V.; Goldberg, R. N.
Journal of Physical Chemistry, 1995 , vol. 99, p. 1594 - 1601
反应条件
Calbiochem protease from Bacillus licheniformis T=50°C; Enzymatic reaction;
参考文献
Zhao, Hua; Baker, Gary A.; Holmes, Shaletha
Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 72, # 3-4 p. 163 - 167
反应条件
Tris-HCl buffer; α-chymotropsin in water; N,N-dimethyl-formamide pH 9;
参考文献
Aso
Agricultural and Biological Chemistry, 1989 , vol. 53, # 3 p. 729 - 733
反应条件
1: 70 percent / ZnCl2 / 8 h / 6 - 8 °C
2: 82 percent / 5 h / Heating
3: 93 percent / HCl / H2O / 16 h / Heating
View Scheme
参考文献
Bo, Liu; Jiarong, Zhan
Synthetic Communications, 1999 , vol. 29, # 13 p. 2293 - 2299
反应条件
1: N-acetyl-L-phenylalanine ethyl ester With pyridine; oxalyl dichloride in tetrahydrofuran
T=0°C; 0.5 h; Inert atmosphere;
2: With Propylene glycol in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
3: benzyl chloroformate With potassium hydrogencarbonate in water; ethyl acetate
T=0 - 20°C; 16 h;
参考文献
Koenig, Stefan G.; Vandenbossche, Charles P.; Zhao, Hang; Mousaw, Patrick; Singh, Surendra P.; Bakale, Roger P.
Organic Letters, 2009 , vol. 11, # 2 p. 433 - 436
