2,4,6-三甲基-N-苯基苯胺合成路线 （共 24 条）
反应条件
(2-mesityl-1H-inden-3-yl)dicyclohexylphosphine; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in ethylene glycol dimethyl ether
T=120°C; Buchwald-Hartwig amination; 24 h; Inert atmosphere;
参考文献
Hao, Xiaowei; Yuan, Jia; Yu, Guang-Ao; Qiu, Ming-Qiang; She, Neng-Fang; Sun, Yue; Zhao, Cui; Mao, Shu-Lan; Yin, Jun; Liu, Sheng-Hua
Journal of Organometallic Chemistry, 2012 , vol. 706-707, p. 99 - 105
反应条件
diaminochlorophosphine ligand; sodium t-butanolate; [Pd(dibenzylideneacetone)2] in toluene
T=105°C; 21 h;
参考文献
Zhu, Lei; Ye, Yue-Mei; Shao, Li-Xiong
Tetrahedron, 2012 , vol. 68, # 10 p. 2414 - 2420
反应条件
indium; copper diacetate in methanol
T=70°C; 4 h;
参考文献
Reddy, B.V. Subba; Reddy, N. Sivasankar; Reddy, Y. Jayasudhan; Reddy, Y. Vikram
Tetrahedron Letters, 2011 , vol. 52, # 20 p. 2547 - 2549
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; [Ni0(1,5-cyclooctadiene)2]; sodium t-butanolate in toluene
T=20 - 105°C; Inert atmosphere;
参考文献
Ackermann, Lutz; Sandmann, Rene; Song, Weifeng
Organic Letters, 2011 , vol. 13, # 7 p. 1784 - 1786
反应条件
potassium hydroxide in various solvent(s)
24 h; Heating;
参考文献
Grellmann, Karl-Heinz; Kuehnle, Wolfgang; Weller, Horst; Wolff, Thomas
Journal of the American Chemical Society, 1981 , vol. 103, # 23 p. 6889 - 6893
反应条件
cesium fluoride in acetonitrile
T=20°C; 10 h;
参考文献
Liu, Zhijian; Larock, Richard C.
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3198 - 3209
反应条件
1: 2,4,6-trimethylbenzenamine With n-butyllithium; ZnCl2*TMEDA in tetrahydrofuran; hexane
T=0 - 20°C; 0.5 h; Inert atmosphereSchlenk technique;
2: phenyl-magnesium bromide With N,N'-dimethyl-N,N'-propyleneurea; bis(acetylacetonate)nickel(II); 1,2-dichloro-2-methylpropane in tetrahydrofuran; hexane
T=0 - 20°C; 3 h; Inert atmosphereSchlenk technique;
参考文献
Ilies, Laurean; Matsubara, Tatsuaki; Nakamura, Eiichi
Organic Letters, 2012 , vol. 14, # 21 p. 5570 - 5573,4
反应条件
C42H46ClF6N3OPd; sodium t-butanolate in 1,4-dioxane
T=80°C; Buchwald-Hartwig amination; 3 h;
参考文献
Jin, Zhong; Qiu, Ling-Ling; Li, Yan-Qing; Song, Hai-Bin; Fang, Jian-Xin
Organometallics, 2010 , vol. 29, # 23 p. 6578 - 6586
反应条件
bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; sodium t-butanolate in 1,4-dioxane
T=75°C; 5 h; Molecular sieveSchlenk technique;
参考文献
Zhang, Xue-Qi; Wang, Zhong-Xia
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 9 p. 1448 - 1453
反应条件
1: bromobenzene With iodine; magnesium in tetrahydrofuran
Grignard reaction; Inert atmosphere;
2: With copper (I) cyanide in tetrahydrofuran
T=0°C; Inert atmosphere;
3: 2,4,6-trimethylphenyl azide in tetrahydrofuran
T=0°C; 2 h; Inert atmosphere;
参考文献
Yadav; Reddy, B.V. Subba; Borkar, Prashant; Reddy, P. Janardhan
Tetrahedron Letters, 2009 , vol. 50, # 48 p. 6642 - 6645
