4-氟-3-三氟甲基苯胺合成路线 （共 17 条）
反应条件
sulfuric acid; water; copper(II) sulfate; urea; sodium nitrite 1.) H2O, 5 deg C, 1 h, 2.) reflux, 2 h; Yield given. Multistep reaction;
参考文献
Nodiff; Tanabe; Chen; Saggiomo
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1097 - 1101
反应条件
hydrogenchloride; sodium hydrogencarbonate; sodium nitrite 2.) 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Yonezawa, Noriyuki; Hino, Tetsuo; Namie, Tsutomu; Katakai, Ryoichi
Synthetic Communications, 1996 , vol. 26, # 8 p. 1575 - 1578
反应条件
1: With hydrogenchloride; sodium nitrite in water 0.333333 h; Cooling with ice; 2: With hydrogenchloride; SnCl2·2H2O in water T=-10 - -5°C; 2 h;
参考文献
Bulletin of the Korean Chemical Society, , vol. 31, # 11 p. 3341 - 3347
反应条件
in tetrahydrofuran
robotic synthesis; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Linclau, Bruno; Sing, Ashvani K.; Curran, Dennis P.
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2835 - 2842
反应条件
N-iodo-succinimide; toluene-4-sulfonic acid in tetrahydrofuran; methanol
参考文献
Lanter, James C.; Sui, Zhihua; Fiordeliso, James J.; Jiang, Weiqin; Zhang, Xuqing
Patent: US2005/250740 A1, 2005 ;
Location in patent: Page/Page column 42 ;
US 20050250740 A1
反应条件
1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere
2.2: 50 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; DENG, Guanghui; LIN, Xichen; REN, Feng; ZHAO, Baowei
Patent: WO2011/134280 A1, 2011 ;
WO 2011/134280 A1
反应条件
in tetrahydrofuran
robotic synthesis; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Linclau, Bruno; Sing, Ashvani K.; Curran, Dennis P.
Journal of Organic Chemistry, 1999 , vol. 64, # 8 p. 2835 - 2842
